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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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Otranto Road Library
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McClellanville Library
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MICRORNA-21 AS NOVEL BIOMARKER FOR PANCREATIC BETA CELLS STRESS AND/OR DEATH IN PATIENTS WITH DIABETES MELLITUS TYPE 1.
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- Author(s): Awad, Hussein Chaseb1; Hussein, Khwam R.2; Khudhair, Hasan Abd Ali2
- Source:
Euromediterranean Biomedical Journal. 2023, p108-114. 7p.- Subject Terms:
- Source:
- Additional Information
- Abstract: The research aimed to detect the roles of vitamin D (VD) and micro-ribonucleic acid (miRNA)-21-5p as potential predictors and diagnostic biomarkers for type 1 diabetes (T1D) and to determine the degree of association and predictability of them on beta (β) cells stress/death. A case-control study included three study groups: a T1D group that comprised 35 newly onset T1D patients, a firstdegree relatives (FDRs) group that included a total of 35 FDRs of T1D patients, and a healthy control (HC) group that included a total of 20 subjects. All study subjects were evaluated for their serum connecting (C) peptide and VD, as well as the expression folds of serum miRNA-21-5p. The findings revealed significantly lower levels of C. peptide and VD among T1D and FDRs subjects than the HC group, whereas the folds of miRNA-21-5p were significantly higher in T1D subjects than FDRs and HC subjects. Furthermore, the level of C. peptide had a valuable positive association with VD within T1D and FDRs groups, whereas the folds of miRNA-21-5p have a valuable positive association with C. peptide and VD in FDRs and T1D groups, respectively. Vitamin D had exhibited a significantly decreased level among T1D and FDRs, and positively correlated with residual β-cells function, which indicated the possible utility of its low level as a β-cells stress/death predictive and diagnostic biomarker. Micro-RNA-21-5p indicated the possible utility of its high folds expression as β-cells stress/death predictive and diagnostic biomarker and the high level of miRNA-21-5p might play a vital role in T1D prevention. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Euromediterranean Biomedical Journal is the property of Segretariato Italiano Medici e Specializzandi (SIMS) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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