T(H)1 cells control themselves by producing interleukin-10.

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  • Author(s): O'Garra A;O'Garra A; Vieira P
  • Source:
    Nature reviews. Immunology [Nat Rev Immunol] 2007 Jun; Vol. 7 (6), pp. 425-8.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print Cited Medium: Print ISSN: 1474-1733 (Print) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London, UK : Nature Pub. Group, [c2001-
    • Subject Terms:
      Models, Immunological*; Interleukin-10/*immunology ; Th1 Cells/*immunology ; Th1 Cells/*metabolism; Animals ; Humans ; Leishmaniasis, Cutaneous/immunology ; Toxoplasmosis/immunology
    • Abstract:
      Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.
    • Number of References:
      51
    • Grant Information:
      MC_U117565642 United Kingdom MRC_ Medical Research Council
    • Accession Number:
      130068-27-8 (Interleukin-10)
    • Publication Date:
      Date Created: 20070526 Date Completed: 20070712 Latest Revision: 20220129
    • Publication Date:
      20240829
    • Accession Number:
      10.1038/nri2097
    • Accession Number:
      17525751