Gastrointestinal symptoms have a non-temporal association with regression in a cohort with autism spectrum disorder using the simons simplex collection.

Autism spectrum disorder (ASD) can present with developmental regression. In this study, we hypothesize an association between Gastrointestinal (GI) symptoms and regression. We conducted a two-part analysis using data from the Simon Simplex Collection consisting of 2564 ASD probands. Independent sample t-tests or chi-squared tests were utilized comparing regression against no-regression groups, and regression in children with and without early onset of GI symptoms. The presence of GI symptoms of any kind is associated with regression (odds ratio= 1.51; 95% CI 1.25 - 2.82; p < 0.001). Early GI effects on subsequent development of regression demonstrate no association (OR=0.81; 95% CI 0.649–1.01; p < 0.062). Although a clear relationship between GI symptoms and regression is demonstrated in this study, the lack of temporal relationship between the two highlight the need for a better understanding of the underlying mechanism behind this phenomenon. • Gastrointestinal Symptoms are associated with autism spectrum disorder. • Autism Spectrum Disorder may be described in two subsets: early onset or regression. • Gastrointestinal symptoms were associated with regression. • Gastrointestinal symptoms did not precede the onset of regression. [ABSTRACT FROM AUTHOR]

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