Body shape and composition in HIV-infected women: an urban cohort.

HIV-positive women; HIV-associated lipodystrophy syndrome; HIV infection complications; ANTIVIRAL agents; VIRAL load; VIROLOGY

Alterations in body shape and composition are associated with HIV/AIDS. Wasting remains prevalent; increasingly, lipodystrophy is reported. Obesity is also epidemic in the USA. In this study, we sought to characterize the body changes reported by women attending a US urban clinic, and to evaluate contributing factors using inexpensive methods that are readily available in clinical practice. In an urban Maryland clinic, a cross-section of HIV-infected women were evaluated by self report, anthropomorphic measurements, bioelectric impedance analysis (BIA) and chart review; they were categorized as no change, lipodystrophy, weight loss/wasting or weight gain/obesity. One hundred and sixty-one women were evaluated: 144 (89%) were African-American; 100 (62%) had used intravenous drugs and 40 (25%) were actively injecting drugs, while 39 (24%) smoked crack. Ninety-five (59%) were on highly active antiretroviral therapy (HAART) for a median period of 11.7 months [interquartile range (IQR)=4.5–24.2]. Since starting current HAART or in the previous year, 12 (7.4%) reported lipodystrophy changes, 85 (52.8%) weight gain, 27 (16.8%) overall weight loss, and 37 (23.0%) no change. Lipodystrophy was associated with higher CD4 percentage ( P=0.03), lower frequency of crack use ( P=0.04) and higher educational level ( P=0.03). Weight loss correlated with longer duration of infection ( P=0.01), select BIA results and increased rate of crack use ( P=0.005). Weight gain was associated with higher fat mass ( P=0.005), higher peak viral load ( P=0.02), and lower rate of intravenous drug use ( P=0.03). Self-reported changes in body shape were common. Obesity and complications of illicit drug use were more prevalent than lipodystrophy in this inner-city population of HIV-positive women. [ABSTRACT FROM AUTHOR]