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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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Mt. Pleasant Library
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Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Phone: (843) 795-6679
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Phone: (843) 805-6930
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Phone: (843) 805-6892
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Prognostic Value of Immunoscore in Colorectal Carcinomas.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Imen, Helal (AUTHOR); Amira, Hmidi (AUTHOR); Fatma, Khanchel (AUTHOR); Raja, Jouini (AUTHOR); Mariem, Sabbah (AUTHOR); Haithem, Zaafouri (AUTHOR); Ehsene, Ben Brahim (AUTHOR); Aschraf, Chadlidebbiche (AUTHOR)
- Source:
International Journal of Surgical Pathology. Feb2024, Vol. 32 Issue 1, p58-65. 8p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Aims. Immunoscore, based on the evaluation of CD3+ and CD8+ densities in the center of the tumor and its invasive margin, is currently considered as a potential prognostic factor, particularly in colorectal carcinomas. In the current study, we aimed to assess the prognostic value of immunoscore in colorectal cancer stage I to IV, through a survival study. Methods and Results. It was a descriptive and retrospective study involving 104 cases of colorectal cancer. Data were collected over 3 years (2014-2016). An immunohistochemical study (anti-CD3, anti-CD8) by the tissue microarray technique was carried out in the areas of "hot spot" in the tumor center and invasive margin. A percentage was assigned to each marker and within each region. Then, the density was classified as "low" or "high," according to a cutoff fixed at the median of percentages. immunoscore was calculated by the method described by Galon et al. The prognostic value of the immunoscore was assessed through a survival study. The mean age of patients was 61.6 years. immunoscore was low in 60.6% (n = 63). Our study had shown that low immunoscore significantly deteriorates survival and a high immunoscore enhances survival significantly (P <.001). We found a correlation between immunoscore and T stage (P =.026). A multivariate showed that the predictive factors for survival were immunoscore (P =.001) and age (P =.035). Conclusions. Our study highlights the potential role of immunoscore as a prognostic factor in colorectal cancer. Its reproducibility and reliability allow its introduction into daily practice for better therapeutic management. [ABSTRACT FROM AUTHOR]
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