[Effect of probiotic lactic acid bacteria strains on virus infection].

Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9318954 Publication Model: Print Cited Medium: Print ISSN: 1028-0987 (Print) Linking ISSN: 10280987 NLM ISO Abbreviation: Mikrobiol Z Subsets: MEDLINE

Original Publication: Kyïv : Naukova Dumka, c1993-

Herpes Simplex/*therapy ; Lactobacillus plantarum/*growth & development ; Orthomyxoviridae Infections/*therapy ; Probiotics/*therapeutic use ; Streptococcus thermophilus/*growth & development; Animals ; Cell Line, Tumor ; Chick Embryo ; Cytopathogenic Effect, Viral ; Disease Models, Animal ; Genital Diseases, Male/therapy ; Genital Diseases, Male/virology ; Guinea Pigs ; HIV-1/drug effects ; Herpes Genitalis/therapy ; Herpes Genitalis/virology ; Herpes Simplex/virology ; Herpesvirus 1, Human/drug effects ; Herpesvirus 2, Human/drug effects ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects ; Lactobacillus plantarum/classification ; Male ; Mice ; Orthomyxoviridae Infections/virology ; Probiotics/administration & dosage ; Streptococcus thermophilus/classification

The effect of probiotic lactic acid bacteria strains on viral infection was studied in experiments in vivo. It was shown that in investigations microbial substance based on living cells of L. plantarum and S. salivarius subsp. thermophilus strains manifested antiinfluenzal activity under administration of 0.3 ml of cultural medium per os at a dose of 3 x 10(8)/CFU mouse and antiherpetic activity at a dose of 0.3 x 10(9)/CFU mouse. The probiotic effectiveness was shown on the model of genital herpes of guinea-pigs at concentration of 1 x 10(9) cells/g.p. It was statistically established, that the lactic acid bacteria inhibited reproduction of HIV at a dose of cells of 0.1 x 10(9)/CFU ml.

Date Created: 20070515 Date Completed: 20070524 Latest Revision: 20070514

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