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[Plasminogen activator from Agkistrodon halys halys venom].
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- Additional Information
- Source:
Publisher: Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina Country of Publication: Ukraine NLM ID: 101657175 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Ukr Biokhim Zh (1999) Subsets: MEDLINE
- Publication Information:
Original Publication: Kyïv : Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina, 1999-2013.
- Subject Terms:
- Abstract:
Plasminogen activator "Ahh-32" from Agkistrodon halys halys venom has been isolated and purified using affinity and ion-exchange chromatography. The purified enzyme consists of the single peptide-chain with molecular weigth of 32 kDa. It can convert free plasminogen into active form--plasmin. "Ahh-32" was inhibited by DFP and benzamidine. Besides, the enzyme influences significantly the activation of plasminogen by streptokinase without having effect on analogical process in case of usage of tissue tipe plasminogen activator. The obtained protein can be used as an instrument under investigation of protein-protein interactions in haemostasis system.
- Accession Number:
0 (Agkistrodon venoms)
0 (Benzamidines)
0 (Crotalid Venoms)
0 (Protease Inhibitors)
12UHW9R67N (Isoflurophate)
EC 3.4.21.- (Plasminogen Activators)
KUE3ZY3J1F (benzamidine)
- Publication Date:
Date Created: 20070515 Date Completed: 20070620 Latest Revision: 20161124
- Publication Date:
20231215
- Accession Number:
17494316
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