Menu
×
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
West Ashley Library
Closed
Phone: (843) 766-6635
Wando Mount Pleasant Library
Closed
Phone: (843) 805-6888
McClellanville Library
Closed
Phone: (843) 887-3699
Folly Beach Library
Closed
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
Closed for renovations
Phone: (843) 869-2355
John L. Dart Library
Closed
Phone: (843) 722-7550
St. Paul's/Hollywood Library
Closed
Phone: (843) 889-3300
Mt. Pleasant Library
Closed
Phone: (843) 849-6161
Dorchester Road Library
Closed
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
Closed
Phone: (843) 883-3914
John's Island Library
Closed
Phone: (843) 559-1945
Otranto Road Library
Closed
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed
Phone: (843) 766-2546
Baxter-Patrick James Island
Closed
Phone: (843) 795-6679
Bees Ferry West Ashley Library
Closed
Phone: (843) 805-6892
Village Library
Closed
Phone: (843) 884-9741
Keith Summey North Charleston Library
Closed
Phone: (843) 744-2489
Mobile Library
Closed
Phone: (843) 805-6909
Today's Hours
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
West Ashley Library
Closed
Phone: (843) 766-6635
Wando Mount Pleasant Library
Closed
Phone: (843) 805-6888
McClellanville Library
Closed
Phone: (843) 887-3699
Folly Beach Library
Closed
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
Closed for renovations
Phone: (843) 869-2355
John L. Dart Library
Closed
Phone: (843) 722-7550
St. Paul's/Hollywood Library
Closed
Phone: (843) 889-3300
Mt. Pleasant Library
Closed
Phone: (843) 849-6161
Dorchester Road Library
Closed
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
Closed
Phone: (843) 883-3914
John's Island Library
Closed
Phone: (843) 559-1945
Otranto Road Library
Closed
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed
Phone: (843) 766-2546
Baxter-Patrick James Island
Closed
Phone: (843) 795-6679
Bees Ferry West Ashley Library
Closed
Phone: (843) 805-6892
Village Library
Closed
Phone: (843) 884-9741
Keith Summey North Charleston Library
Closed
Phone: (843) 744-2489
Mobile Library
Closed
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Jiang, Enoch X.; Domingo-Relloso, Arce; Abuawad, Ahlam; Haack, Karin; Tellez-Plaza, Maria; Fallin, M. Danielle; Umans, Jason G.; Best, Lyle G.; Ying Zhang; Kupsco, Allison; Belsky, Daniel W.; Cole, Shelley A.; Navas-Acien, Ana
- Source:
Environmental Health Perspectives. Dec2023, Vol. 131 Issue 12, p127016-1-127016-12. 12p. - Source:
- Additional Information
- Subject Terms: MORTALITY risk factors; HEART physiology; CARDIOVASCULAR diseases risk factors; RESEARCH; NATIVE Americans; CARDIOVASCULAR system physiology; ARSENIC; ARSENIC poisoning; AGE distribution; HEALTH status indicators; REGRESSION analysis; DISEASE incidence; RISK assessment; DNA methylation; AGING; RESEARCH funding; DESCRIPTIVE statistics; SURVIVAL analysis (Biometry); FACTOR analysis; STATISTICAL correlation; DATA analysis software; ENVIRONMENTAL exposure; EPIGENOMICS; LONGITUDINAL method; PHENOTYPES; DISEASE complications
- Abstract: BACKGROUND: Inorganic arsenic (As) may increase the risk of cardiovascular disease (CVD) and all-cause mortality through accelerated aging, which can be estimated using epigenetic-based measures. OBJECTIVES: We evaluated three DNA methylation-based aging measures (PhenoAge, GrimAge, DunedinPACE) (epigenetic aging measures) as potential mediators of the previously reported association of As exposure with CVD incidence, CVD mortality, and all-cause mortality in the Strong Heart Study (SHS), an epidemiological cohort of American Indian adults. METHODS: Blood DNA methylation and urinary As levels were measured in 2,323 SHS participants (41.5% men, mean age of 55 years old). PhenoAge and GrimAge values were calculated using a residual-based method. We tested the association of urinary As with epigenetic aging measures using linear regression, the association of epigenetic aging measures with the three health outcomes using additive hazards models, and the mediation of As-related CVD incidence, CVD mortality, and all-cause mortality by epigenetic aging measures using the product of coefficients method. RESULTS: SHS participants with higher vs. lower urinary As levels had similar PhenoAge age, older GrimAge age, and faster DunedinPACE. An interquartile range increase in urinary As was associated with higher of PhenoAge age acceleration [mean difference (95% confidence interval)=0.48 (0.17, 0.80) years], GrimAge age acceleration [0.80 (0.60, 1.00) years], and DunedinPACE [0.011 (0.005, 0.018)], after adjusting for age, sex, center location, genetic components, smoking status, and body mass index. Of the 347 incident CVD events per 100,000 person-years associated with a doubling in As exposure, 21.3% (9.1, 57.1) and 22.6% (9.5, 56.9), were attributable to differences in GrimAge and DunedinPACE, respectively. DISCUSSION: Arsenic exposure was associated with older GrimAge and faster DunedinPACE measures of biological age. Furthermore, accelerated biological aging measured from DNA methylation accounted for a relevant fraction of As-associated risk for CVD, CVD mortality, and all-cause mortality in the SHS, supporting the role of As in accelerated aging. Research of the biological underpinnings can contribute to a better understanding of the role of aging in arsenic-related disease. [ABSTRACT FROM AUTHOR]
- Subject Terms:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.