Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force.

The article focuses on the investigation of truncated titin proteins (TTNtvs) in dilated cardiomyopathy (DCM), elucidating their presence and integration into the sarcomere, thereby influencing sarcomeric structure and function. Topics discussed include the development of a patient-specific antibody for TTNtv detection, their incorporation into the sarcomere, and their capacity to bear load across the sarcomere.