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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
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West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
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Otranto Road Library
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Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 805-6930
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Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders.
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- Author(s): Eratne, Dhamidhu (AUTHOR); Kang, Matthew (AUTHOR); Malpas, Charles (AUTHOR); Simpson-Yap, Steve (AUTHOR); Lewis, Courtney (AUTHOR); Dang, Christa (AUTHOR); Grewal, Jasleen (AUTHOR); Coe, Amy (AUTHOR); Dobson, Hannah (AUTHOR); Keem, Michael (AUTHOR); Chiu, Wei-Hsuan (AUTHOR); Kalincik, Tomas (AUTHOR); Ooi, Suyi (AUTHOR); Darby, David (AUTHOR); Brodtmann, Amy (AUTHOR); Hansson, Oskar (AUTHOR); Janelidze, Shorena (AUTHOR); Blennow, Kaj (AUTHOR); Zetterberg, Henrik (AUTHOR); Walker, Adam (AUTHOR)
- Source:
Australian & New Zealand Journal of Psychiatry. Jan2024, Vol. 58 Issue 1, p70-81. 12p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show promise to improve diagnosis of neurodegenerative disorders and distinguish neurodegenerative from primary psychiatric disorders (PPD). This study investigated the diagnostic utility of plasma NfL to differentiate behavioural variant frontotemporal dementia (bvFTD, a neurodegenerative disorder commonly misdiagnosed initially as PPD), from PPD, and performance of large normative/reference data sets and models. Methods: Plasma NfL was analysed in major depressive disorder (MDD, n = 42), bipolar affective disorder (BPAD, n = 121), treatment-resistant schizophrenia (TRS, n = 82), bvFTD (n = 22), and compared to the reference cohort (Control Group 2, n = 1926, using GAMLSS modelling), and age-matched controls (Control Group 1, n = 96, using general linear models). Results: Large differences were seen between bvFTD (mean NfL 34.9 pg/mL) and all PPDs and controls (all < 11 pg/mL). NfL distinguished bvFTD from PPD with high accuracy, sensitivity (86%), and specificity (88%). GAMLSS models using reference Control Group 2 facilitated precision interpretation of individual levels, while performing equally to or outperforming models using local controls. Slightly higher NfL levels were found in BPAD, compared to controls and TRS. Conclusions: This study adds further evidence on the diagnostic utility of NfL to distinguish bvFTD from PPD of high clinical relevance to a bvFTD differential diagnosis, and includes the largest cohort of BPAD to date. Using large reference cohorts, GAMLSS modelling and the interactive Internet-based application we developed, may have important implications for future research and clinical translation. Studies are underway investigating utility of plasma NfL in diverse neurodegenerative and primary psychiatric conditions in real-world clinical settings. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Australian & New Zealand Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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