Effect of mitomycin C and bromodeoxyuridine on Fanconi anemia lymphocytes.

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  • Author(s): Frias S;Frias S; Mendoza S; Molina B; Carnevale A
  • Source:
    Annales de genetique [Ann Genet] 1991; Vol. 34 (2), pp. 104-7.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370562 Publication Model: Print Cited Medium: Print ISSN: 0003-3995 (Print) Linking ISSN: 00033995 NLM ISO Abbreviation: Ann Genet Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Paris.
    • Subject Terms:
      Bromodeoxyuridine/*toxicity ; Chromosome Aberrations/*genetics ; Fanconi Anemia/*genetics ; Lymphocytes/*drug effects ; Mitomycin/*toxicity; Child ; Humans
    • Abstract:
      The authors studied the effect of mitomycin C (MMC) and bromodeoxyuridine (BrdU) on the induction of chromosome aberrations on lymphocytes of four patients with Fanconi anemia (FA) and of one normal subject. A control culture and six experiments were designed to test the possible synergic effect of MMC and BrdU. Their results revealed no evidence of MMC-BrdU synergism on the induction of chromosome aberrations in FA lymphocytes. However, chromosomes showed more damage when FA cells were harvested 24 h after MMC stress than when cells were harvested shortly after treatment. This can be explained by a DNA repair defect or by a toxic effect of oxygenation of cells during the procedure.
    • Accession Number:
      50SG953SK6 (Mitomycin)
      G34N38R2N1 (Bromodeoxyuridine)
    • Publication Date:
      Date Created: 19910101 Date Completed: 19920113 Latest Revision: 20131121
    • Publication Date:
      20240829
    • Accession Number:
      1746878