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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Wando Mount Pleasant Library
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Phone: (843) 805-6888
McClellanville Library
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Folly Beach Library
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Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
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Phone: (843) 869-2355
John L. Dart Library
9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
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Mt. Pleasant Library
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Edgar Allan Poe/Sullivan's Island Library
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John's Island Library
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Multidimensional progressive single‐cell sequencing reveals cell microenvironment composition and cancer heterogeneity in lung cancer.
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- Author(s): Chen, Hua1,2 (AUTHOR) ; Song, Anqi3 (AUTHOR); UL Rehman, Faisal4 (AUTHOR); Han, Dan5 (AUTHOR)
- Source:
Environmental Toxicology. Feb2024, Vol. 39 Issue 2, p890-904. 15p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Despite substantial advances in cancer biology and treatment, the clinical outcomes of patients with lung cancer remain unsatisfactory. The tumor microenvironment (TME) is a potential target. Using single‐cell RNA sequencing, we could distinguish eight distinct cell types in the lung cancer microenvironment, demonstrating substantial intratumoral heterogeneity in 19 different lung cancer tumor samples. Through the re‐dimensional grouping of cancer‐associated fibroblasts (CAFs), myeloid cells, epithelial cells, natural killer (NK) cells, and T cells, the difference in the TME of lung cancer was revealed. We discovered SFTPB, SFN, and KRT8 as possible predictive biomarkers for lung cancer by assessing the gene expression patterns in epithelial cells. Examining cell‐to‐cell communications showed a robust association between the quantity of matrix CAFs, epithelial cells, and macrophages in the thrombospondin signaling pathway. Additionally, we found that the amyloid precursor protein signaling pathway primarily originated from the matrix, and inflammatory cancer‐associated endothelial and fibroblast cells showed a co‐expression relationship with myeloid cells and B cells. Through cell‐to‐cell correlation analysis, we found positive regulation between NK cells, regulatory T cells, GZMB‐CD8 T cells, and GZMK‐CD8 T cells, which could play a role in developing immune TMEs. These findings support studies on cancer heterogeneity and add to our understanding of lung cancer's cellular microenvironment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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