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In vitro hemocompatibility screening of a slippery liquid impregnated surface coating for extracorporeal organ support applications.
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- Author(s): Roberts, Teryn R; Seekell, Raymond P; Zang, Yanyi; Harea, George; Zhang, Zheng; Batchinsky, Andriy I
- Source:
Perfusion. Jan2024, Vol. 39 Issue 1, p76-84. 9p. - Source:
- Additional Information
- Subject Terms: IN vitro studies; ARTIFICIAL blood circulation; MEDICAL equipment contamination; SCANNING electron microscopy; EXTRACORPOREAL membrane oxygenation; BLOOD coagulation; EXTRACORPOREAL carbon dioxide removal; BIOFILMS; BIOMEDICAL materials; VINYL chloride; MATERIALS testing; RESEARCH funding; DESCRIPTIVE statistics; POLYMERS; FIBRINOGEN; BLOOD testing; SURFACE properties; DATA analysis software; SURFACE tension; FOREIGN bodies; PREVENTION
- Abstract: Introduction: Clot formation, infection, and biofouling are unfortunate but frequent complications associated with the use of blood-contacting medical devices. The challenge of blood-foreign surface interactions is exacerbated during medical device applications involving substantial blood contact area and extended duration of use, such as extracorporeal life support (ECLS). We investigated a novel surface modification, a liquid-impregnated surface (LIS), designed to minimize protein adsorption and thrombus development on medical plastics. Methods: The hemocompatibility and efficacy of LIS was investigated first in a low-shear model with LIS applied to the lumen of blood incubation vials and exposed to human whole blood. Additionally, LIS was evaluated in a 6 h ex vivo circulation model with swine blood using full-scale ECLS circuit tubing and centrifugal pumps with clinically relevant flow rate (1.5 L/min) and shear conditions for extracorporeal carbon dioxide removal. Results: Under low-shear, LIS preserved fibrinogen concentration in blood relative to control polymers (+40 ± 6 mg/dL vs polyvinyl chloride, p <.0001), suggesting protein adsorption was minimized. A fibrinogen adhesion assay demonstrated a dramatic reduction in protein adsorption under low shear (87% decrease vs polyvinyl chloride, p =.01). Thrombus deposition and platelet adhesion visualized by scanning electron microscopy were drastically reduced. During the 6 h ex vivo circulation, platelets in blood exposed to LIS tubing did not become significantly activated or procoagulant, as occurred with control tubing; and again, thrombus deposition was visually reduced. Conclusions: A LIS coating demonstrated potential to reduce thrombus formation on medical devices. Further testing is needed specialized to clinical setting and duration of use for specific medical target applications. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Perfusion is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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