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Hurd/St. Andrews Library
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Retrospective Study of Treatment Patterns and Natural History of Patients with T1a/b N0 Triple-Negative Breast Cancers: A Single-Institution Experience.
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- Author(s): Liu, Langfeier; Lewis, Nicholas; Sun, Weihong; Whiting, Junmin; Hoover, Susan; Costa, Ricardo L.B.
- Source:
Oncology; 2023, Vol. 101 Issue 12, p765-772, 8p- Subject Terms:
BREAST tumor treatment; KRUSKAL-Wallis Test; CONFIDENCE intervals; LOG-rank test; IMMUNOHISTOCHEMISTRY; RETROSPECTIVE studies; FISHER exact test; TUMOR classification; RESEARCH funding; CHI-squared test; KAPLAN-Meier estimator; GENE expression profiling; ODDS ratio; CANCER patient medical care; BREAST tumors; LONGITUDINAL method; PROPORTIONAL hazards models - Source:
- Additional Information
- Abstract: Introduction: T1a/b, node-negative (node−), triple-negative breast cancers (TNBCs) are underrepresented in randomized drug-approving clinical trials. Given their low incidence, the clinicopathological features, natural history, and treatment patterns of these tumors remain insufficiently understood. Methods: We conducted a single-institution retrospective cohort study of patients with T1a/b, N0, M0 TNBCs. Deidentified patient- and tumor-related data were collected and summarized. Kruskal-Wallis, χ2, or Fisher exact tests were used to evaluate associations of interest. Kaplan-Meier methods, log-rank tests, and Cox's proportional hazards models were applied for survival analyses. Results: Of 108 cases of node– TNBCs measuring ≤2 cm, 34 node– T1a/b tumors were included in our analysis. All cases had an intermediate to high histological grade, and most had a Ki-67 score of ≥20%. All patients received adjuvant chemotherapy, and many underwent mastectomy (47%). Docetaxel combined with cyclophosphamide was the most common adjuvant chemotherapy regimen (75%). We did not observe significant associations between improved outcomes and treatment with anthracycline-containing regimens. Among patients with node– pT1a/b tumors, the estimated 3-year recurrence-free survival (RFS) and distant RFS rates were both 96.3% (95% CI: 76.5–99.5), and the overall survival rate was estimated to be 100% (95% CI: 100–100). There were no cases of local recurrences observed. Conclusions: In our cohort, all patients with T1a/b node– TNBCs were treated with adjuvant chemotherapy and had favorable outcomes even when treated with anthracycline-sparing regimens. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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