Regulation of transcription patterns, poly-ADP-ribose, and RNA-DNA hybrids by the ATM protein kinase.

According to a preprint abstract from biorxiv.org, the ATM protein kinase plays a crucial role in regulating the DNA damage response and sensing oxidative stress. Analysis of gene expression in Ataxia-telangiectasia patient brain tissue reveals significant transcriptional changes in the cerebellum, which are correlated with the expression level and GC content of transcribed genes. In neuron-like cells, the accumulation of poly-ADP-ribose and RNA-DNA hybrids is found to coincide with high transcription levels, active transcription histone marks, and high GC content. The researchers suggest that these transcription-associated lesions may accumulate in ATM-deficient cells, leading to compromised cerebellum function and neurodegeneration over time in A-T patients. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

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