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Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
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- Author(s): Yang, Haitao1,2 (AUTHOR); Xie, Weiqing3 (AUTHOR); Xue, Xiaoyu1,2 (AUTHOR); Yang, Kailin1,2 (AUTHOR); Ma, Jing1,2 (AUTHOR); Liang, Wenxue4 (AUTHOR); Zhao, Qi1,2 (AUTHOR); Zhou, Zhe1,2 (AUTHOR); Pei, Duanqing5 (AUTHOR); Ziebuhr, John6 (AUTHOR); Hilgenfeld, Rolf7 (AUTHOR); Yuen, Kwok Yung8 (AUTHOR); Wong, Luet9 (AUTHOR); Gao, Guangxia1,2 (AUTHOR); Chen, Saijuan4 (AUTHOR); Chen, Zhu4 (AUTHOR); Ma, Dawei3 (AUTHOR) ; Bartlam, Mark1,2 (AUTHOR); Rao, Zihe1,2 (AUTHOR)
- Source:
PLoS Biology. 9/6/2005, Vol. 3 Issue 9, p1-11. 11p.- Subject Terms:
- Source:
- Additional Information
- Abstract: The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their infection. Different host receptors for cellular entry, poorly conserved structural proteins (antigens), and the high mutation and recombination rates of CoVs pose a significant problem in the development of wide-spectrum anti-CoV drugs and vaccines. CoV main proteases (Mpros), which are key enzymes in viral gene expression and replication, were revealed to share a highly conservative substrate-recognition pocket by comparison of four crystal structures and a homology model representing all three genetic clusters of the genus Coronavirus. This conclusion was further supported by enzyme activity assays. Mechanism-based irreversible inhibitors were designed, based on this conserved structural region, and a uniform inhibition mechanism was elucidated from the structures of Mpro-inhibitor complexes from severe acute respiratory syndrome-CoV and porcine transmissible gastroenteritis virus. A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays. Further modification could rapidly lead to the discovery of a single agent with clinical potential against existing and possible future emerging CoV-related diseases. Structure-assisted optimization of compounds capable of inactivating CoV Mpros may rapidly lead to an antiviral agent against Coronavirus-associated diseases. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS Biology is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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