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John L. Dart Library
Closed for Maintenance
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 2 p.m.
*open the 2nd and 4th Saturday
*open the 2nd and 4th Saturday
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 5 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 5 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. – 1 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 5 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 5 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 5 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
9 a.m. - 5 p.m.
Phone: (843) 552-6466
Baxter-Patrick James Island
9 a.m. - 5 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 5 p.m.
Phone: (843) 805-6930
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Phone: (843) 805-6892
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Closed
Phone: (843) 805-6909
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Patient-reported outcomes in high-risk HR+ /HER2- early breast cancer patients treated with endocrine therapy with or without palbociclib within the randomized PENELOPEB study.
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- Author(s): García-Sáenz, José Angel1 (AUTHOR); Marmé, Frederik2 (AUTHOR); Untch, Michael3 (AUTHOR); Bonnefoi, Hervé4 (AUTHOR); Kim, Sung-Bae5 (AUTHOR); Bear, Harry6 (AUTHOR); Mc Carthy, Nicole7 (AUTHOR); Gelmon, Karen8 (AUTHOR); Martin, Miguel9 (AUTHOR); Kelly, Catherine M.10 (AUTHOR); Reimer, Toralf11 (AUTHOR); Toi, Masakazu12 (AUTHOR); Law, Ernest13 (AUTHOR); Bhattacharyya, Helen13 (AUTHOR); Gnant, Michael14 (AUTHOR); Makris, Andreas15 (AUTHOR); Seiler, Sabine16 (AUTHOR); Burchardi, Nicole16 (AUTHOR); Nekljudova, Valentina16 (AUTHOR); Loibl, Sibylle1,16 (AUTHOR)
- Source:
European Journal of Cancer. Jan2024, Vol. 196, pN.PAG-N.PAG. 1p.- Subject Terms:
*THERAPEUTIC use of antineoplastic agents; *EPIDERMAL growth factor receptors; *HEALTH outcome assessment; *HEALTH status indicators; *CYCLIN-dependent kinases; *QUESTIONNAIRES; *QUALITY of life; *REPEATED measures design; *DESCRIPTIVE statistics; *BODY movement; *FATIGUE (Physiology); *BREAST tumors; *LONGITUDINAL method; *CHEMICAL inhibitors; *EVALUATION - Source:
- Additional Information
- Abstract: The PENELOPEB trial investigating efficacy and safety of additional 1-year post-neoadjuvant palbociclib to standard endocrine therapy (ET) high-risk hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer patients failed to improve invasive disease-free survival (iDFS). This analysis compared patient-reported outcomes (PROs) between treatment groups. Patients received 13 cycles of palbociclib 125 mg/day (n = 631) or placebo (n = 619) orally for 3 out of 4 weeks + ET. European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire (EORTC QLQ-C30), its breast cancer (BR23) and fatigue (FA13) modules, mood questionnaire GAD7 and European Quality of Life 5 Dimensions (EQ-5D) instruments were used for the assessment of quality of life (QoL). Repeated-measures mixed-effects models were used to evaluate differences in PRO, changes of PRO over time, and treatment-by-time interactions. 924 of 1250 patients (73.9%) completed baseline and at least one post-baseline questionnaire of all PRO instruments. General health status (GHS)/QoL based on EORTC QLQ-C30 was high in both arms (mean [SD]: palbociclib 70.1 [19.3], placebo 71.4 [18.8]) and was slightly higher in the placebo arm (LeastSquare mean difference: 0.82, p < 0.001). Higher fatigue was reported in the palbociclib arm (mean [SD]: 30.3 [23.8] vs. placebo 28.3 [22.7]; p < 0.001). No statistically significant differences were observed among FA13 physical, cognitive, and emotional fatigue subscales. Patient-reported global QoL and fatigue did not substantially change in both treatment arms. Slight differences in GHS, physical functioning, and fatigue favored the placebo arm statistically without achieving clinically meaningful thresholds. • The addition of palbociclib to standard adjuvant ET did not improve iDFS in general. • Patient-reported global QoL was maintained during the study in both treatment arms. • Slight differences in questionnaires: statistically benefitted the placebo group. • These slight differences did not meet published clinically meaningful thresholds. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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