Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Wong CK;Wong CK; Ho AW; Tong PC; Yeung CY; Kong AP; Lun SW; Chan JC; Lam CW
- Source:
Clinical and experimental immunology [Clin Exp Immunol] 2007 Jul; Vol. 149 (1), pp. 123-31. Date of Electronic Publication: 2007 Apr 11.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
- Publication Information: Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications - Subject Terms: Cytokines/*blood ; Diabetes Mellitus, Type 2/*immunology ; Diabetic Nephropathies/*immunology ; Mitogen-Activated Protein Kinases/*blood; Adiponectin/blood ; Adult ; Cells, Cultured ; Chemokines/biosynthesis ; Chemokines/blood ; Cytokines/biosynthesis ; Extracellular Signal-Regulated MAP Kinases/blood ; Female ; Humans ; Interleukin-18/immunology ; Male ; Middle Aged ; Monocytes/enzymology ; Phosphorylation ; T-Lymphocytes, Helper-Inducer/enzymology ; Tumor Necrosis Factor-alpha/immunology ; p38 Mitogen-Activated Protein Kinases/blood
- Abstract: Cytokine-induced inflammation is involved in the pathogenesis of type 2 diabetes mellitus (DM). We investigated plasma concentrations and ex vivo production of cytokines and chemokines, and intracellular signalling molecules, mitogen-activated protein kinases (MAPK) in T helper (Th) cells and monocytes in 94 type 2 diabetic patients with or without nephropathy and 20 healthy controls. Plasma concentrations of inflammatory cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-18 and chemokine CCL2 in patients with diabetic nephropathy (DN) were significantly higher than control subjects, while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) and control subjects (all P < 0.05). Plasma concentrations of TNF-alpha, IL-6, IL-10, IL-18, CCL2, CXCL8, CXCL9, CXCL10 and adiponectin exhibited significant positive correlation with urine albumin : creatinine ratio in DN patients. The percentage increases of ex vivo production of IL-6, CXCL8, CXCL10, CCL2 and CCL5 upon TNF-alpha activation were significantly higher in both NDN and DN patients than controls (all P < 0.05). The percentage increases in IL-18-induced phosphorylation of extracellular signal-regulated kinase (ERK) in Th cells of NDN and DN were significantly higher than controls (P < 0.05), while the percentage increase in TNF-alpha-induced phosphorylation of p38 MAPK in monocytes and IL-18-induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls. These results confirmed that the aberrant production of inflammatory cytokines and chemokines and differential activation of MAPK in different leucocytes are the underlying immunopathological mechanisms of type 2 DM patients with DN.
- References: Clin Exp Immunol. 2000 Sep;121(3):437-43. (PMID: 10971508)
Biochim Biophys Acta. 2007 Aug;1773(8):1299-310. (PMID: 17188374)
Physiol Rev. 2001 Apr;81(2):807-69. (PMID: 11274345)
J Clin Endocrinol Metab. 2001 May;86(5):1930-5. (PMID: 11344187)
J Clin Lab Anal. 2002;16(1):1-4. (PMID: 11835523)
Clin Sci (Lond). 2002 Aug;103(2):137-42. (PMID: 12149104)
Circulation. 2002 Oct 15;106(16):2067-72. (PMID: 12379575)
Nature. 2002 Nov 21;420(6913):333-6. (PMID: 12447443)
Circulation. 2003 Feb 11;107(5):671-4. (PMID: 12578865)
Free Radic Res. 2002 Dec;36(12):1331-6. (PMID: 12607825)
Kidney Int Suppl. 2003 May;(84):S98-102. (PMID: 12694320)
Diabetes Care. 2003 May;26(5):1647. (PMID: 12716849)
Diabetologia. 2003 Oct;46(10):1324-8. (PMID: 12937895)
Diabetologia. 2003 Dec;46(12):1594-603. (PMID: 14605806)
Eur Cytokine Netw. 2003 Jul-Sep;14(3):128-33. (PMID: 14656685)
Diabetes Care. 2004 Mar;27(3):813-23. (PMID: 14988310)
Biochem Biophys Res Commun. 2004 Mar 26;316(1):165-9. (PMID: 15003525)
Clin Immunol. 2004 Mar;110(3):206-21. (PMID: 15047199)
Diabetologia. 2004 Mar;47(3):532-6. (PMID: 14762656)
J Immunol. 2004 Jun 15;172(12):7841-7. (PMID: 15187168)
J Biol Chem. 2004 Jul 23;279(30):31930-6. (PMID: 15145956)
Diabetologia. 2004 Jul;47(7):1210-22. (PMID: 15232685)
Nat Med. 2004 Oct;10(10):1128-32. (PMID: 15448687)
J Biol Chem. 1995 Nov 10;270(45):26746-9. (PMID: 7592907)
Diabetes. 1996 Jul;45(7):954-9. (PMID: 8666148)
Clin Exp Immunol. 1999 Jan;115(1):189-95. (PMID: 9933441)
Am J Physiol. 1999 May;276(5 Pt 1):E849-55. (PMID: 10329978)
Clin Exp Immunol. 2005 Jan;139(1):90-100. (PMID: 15606618)
Ital J Biochem. 2004 Jul;53(2):73-81. (PMID: 15646011)
Biochem Biophys Res Commun. 2005 Feb 18;327(3):707-12. (PMID: 15649404)
Diabetes Care. 2005 Jun;28(6):1410-4. (PMID: 15920060)
Am J Respir Cell Mol Biol. 2005 Aug;33(2):186-94. (PMID: 15860795)
Clin Immunol. 2005 Nov;117(2):152-60. (PMID: 16112617)
Nephrol Dial Transplant. 2005 Dec;20(12):2733-8. (PMID: 16141456)
Immunol Invest. 2007;36(1):47-57. (PMID: 17190649)
Am J Nephrol. 2006;26(5):476-82. (PMID: 17095862)
Free Radic Biol Med. 2000 Oct 15;29(8):790-2. (PMID: 11053781) - Accession Number: 0 (Adiponectin)
0 (Chemokines)
0 (Cytokines)
0 (Interleukin-18)
0 (Tumor Necrosis Factor-alpha)
EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases) - Publication Date: Date Created: 20070412 Date Completed: 20070823 Latest Revision: 20220409
- Publication Date: 20221213
- Accession Number: PMC1942021
- Accession Number: 10.1111/j.1365-2249.2007.03389.x
- Accession Number: 17425653
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.