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Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma.
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- Author(s): Zannas, Anthony S. (AUTHOR); Linnstaedt, Sarah D. (AUTHOR); An, Xinming (AUTHOR); Stevens, Jennifer S. (AUTHOR); Harnett, Nathaniel G. (AUTHOR); Roeckner, Alyssa R. (AUTHOR); Oliver, Katelyn I. (AUTHOR); Rubinow, David R. (AUTHOR); Binder, Elisabeth B. (AUTHOR); Koenen, Karestan C. (AUTHOR); Ressler, Kerry J. (AUTHOR); McLean, Samuel A. (AUTHOR)
- Source:
Psychological Medicine. Nov2023, Vol. 53 Issue 15, p7170-7179. 10p. - Source:
- Additional Information
- Subject Terms: INJURY complications; DIAGNOSIS of post-traumatic stress disorder; MEMORY; HOSPITAL emergency services; DNA; BASAL ganglia; POST-traumatic stress disorder; DNA methylation; AGING; DREAMS; RESEARCH funding; AMYGDALOID body; EPIGENOMICS; LONGITUDINAL method; NEURORADIOLOGY; SECONDARY analysis; PHENOTYPES
- Abstract: Background: Psychological trauma exposure and posttraumatic stress disorder (PTSD) have been associated with advanced epigenetic age. However, whether epigenetic aging measured at the time of trauma predicts the subsequent development of PTSD outcomes is unknown. Moreover, the neural substrates underlying posttraumatic outcomes associated with epigenetic aging are unclear. Methods: We examined a multi-ancestry cohort of women and men (n = 289) who presented to the emergency department (ED) after trauma. Blood DNA was collected at ED presentation, and EPIC DNA methylation arrays were used to assess four widely used metrics of epigenetic aging (HorvathAge, HannumAge, PhenoAge, and GrimAge). PTSD symptoms were evaluated longitudinally at the time of ED presentation and over the ensuing 6 months. Structural and functional neuroimaging was performed 2 weeks after trauma. Results: After covariate adjustment and correction for multiple comparisons, advanced ED GrimAge predicted increased risk for 6-month probable PTSD diagnosis. Secondary analyses suggested that the prediction of PTSD by GrimAge was driven by worse trajectories for intrusive memories and nightmares. Advanced ED GrimAge was also associated with reduced volume of the whole amygdala and specific amygdala subregions, including the cortico-amygdaloid transition and the cortical and accessory basal nuclei. Conclusions: Our findings shed new light on the relation between biological aging and trauma-related phenotypes, suggesting that GrimAge measured at the time of trauma predicts PTSD trajectories and is associated with relevant brain alterations. Furthering these findings has the potential to enhance early prevention and treatment of posttraumatic psychiatric sequelae. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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