In vitro susceptibility of 15 strains of zygomycetes to nine antifungal agents as determined by the NCCLS M38-A microdilution method.

The in vitro susceptibility of 15 strains of six genera of zygomycetes including Rhizopus oryzae ( Rhizopus arrhizus), Rhizopus stolonifer, Mucor circinelloides (three), Absidia corymbifera (three), Rhizomucor pusillus (three), Cunninghamella bertholletiae (two), and Syncephalastrum racemosum (two) to nine antifungal agents were determined by the NCCLS M38-A broth microdilution method. Geometric means of the minimal inhibitory concentrations (MIC) were: amphotericin B 0.07 mg l−1 (range 0.03–0.5 mg l−1), nystatin 0.83 mg l−1 (range 0.25–4 mg l−1), itraconazole 0.59 mg l−1 (range 0.03 to >8 mg l−1), voriconazole 6.50 mg l−1 (range 2 to >8 mg l−1), ciclopiroxolamine 1.59 mg l−1 (range 0.5–4 mg l−1), and amorolfine 9.19 mg l−1 (range 1 to >16 mg l−1). All strains were resistant to 5-flucytosine, fluconazole (MIC >64 mg l−1) and caspofungin (MIC >16 mg l−1). [ABSTRACT FROM AUTHOR]

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