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Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. - 8 p.m.
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Phone: (843) 795-6679
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Phone: (843) 805-6930
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Phone: (843) 805-6892
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Association of magnetic resonance imaging phenotypes and serum biomarker levels with treatment response and long‐term disease outcomes in multiple sclerosis patients.
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- Author(s): Midaglia, Luciana (AUTHOR); Rovira, Alex (AUTHOR); Miró, Berta (AUTHOR); Río, Jordi (AUTHOR); Fissolo, Nicolás (AUTHOR); Castilló, Joaquín (AUTHOR); Sánchez, Alex (AUTHOR); Montalban, Xavier (AUTHOR); Comabella, Manuel (AUTHOR)
- Source:
European Journal of Neurology. Jan2024, Vol. 31 Issue 1, p1-10. 10p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Background and purpose: The aim was to evaluate whether magnetic resonance imaging (MRI) phenotypes defined by inflammation and neurodegeneration markers correlate with serum levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in relapsing–remitting multiple sclerosis (RRMS) patients; and to explore the role of radiological phenotypes and biomarker levels on treatment response and long‐term prognostic outcomes. Methods: Magnetic resonance imaging scans from 80 RRMS patients were classified at baseline of interferon‐beta (IFNβ) treatment into radiological phenotypes defined by high and low inflammation and high and low neurodegeneration, based on the number of contrast‐enhancing lesions, brain parenchymal fraction and the relative volume of non‐enhancing black holes on T1‐weighted images. Serum levels of NfL and GFAP were measured at baseline with single molecule array (Simoa) assays. MRI phenotypes and serum biomarker levels were investigated for their association with IFNβ response, and times to second‐line therapies, secondary‐progressive MS (SPMS) conversion and Expanded Disability Status Scale (EDSS) 6.0. Results: Mean (SD) follow‐up was 17 (2.9) years. Serum NfL levels and GFAP were higher in the high inflammation (p = 0.04) and high neurodegeneration phenotypes (p = 0.03), respectively. The high inflammation phenotype was associated with poor response to IFNβ treatment (p = 0.04) and with shorter time to second‐line therapies (p = 0.04). In contrast, the high neurodegeneration phenotype was associated with shorter time to SPMS (p = 0.006) and a trend towards shorter time to EDSS 6.0 (p = 0.09). High serum NfL levels were associated with poor response to IFNβ treatment (p = 0.004). Conclusions: Magnetic resonance imaging phenotypes defined by inflammation and neurodegeneration correlate with serum biomarker levels, and both have prognostic implications in treatment response and long‐term disease outcomes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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