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Enzymatic antioxidants activity in gingival crevicular fluid and saliva in advanced periodontitis.
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- Author(s): Toczewska, Joanna; Zalewska, Anna; Konopka, Tomasz; Maciejczyk, Mateusz
- Source:
Oral Diseases; Nov2023, Vol. 29 Issue 8, p3559-3570, 12p- Subject Terms:
THERAPEUTIC use of antioxidants; ENZYME metabolism; SALIVA analysis; PROTEINS; DISEASE progression; DENTAL plaque; PERIODONTITIS; SUPEROXIDE dismutase; OXIDATIVE stress; PEROXIDASE; EXUDATES & transudates; DESCRIPTIVE statistics; RESEARCH funding; GINGIVA; GLUTATHIONE peroxidase; DISEASE complications - Source:
- Additional Information
- Abstract: Aim: Enzymatic antioxidants are the primary line of defense against oxidative and nitrosative stress. However, their involvement in the progression of periodontitis is still not well understood. The study aimed to determine the activity of enzymatic antioxidants in the gingival crevicular fluid (GCF) and saliva of patients with periodontitis. Materials and methods: The study group of 56 patients with periodontitis (stage III and IV) and 28 healthy controls were involved. The modified plaque index, probing depth, the clinical attachment level, the percentage of sites with bleeding on probing, papilla bleeding index, and maximum value of tooth mobility (Periotest®) were tested. Saliva (stimulated and non‐stimulated) and GCF were collected from the participants, and activity of peroxidase, catalase, superoxide dismutase, and glutathione reductase were determined colorimetrically. Results: Lower activity of peroxidase (p < 0.0001), catalase (p < 0.0001), superoxide dismutase (p = 0.0188), and glutathione reductase (p < 0.0001) was noted in non‐stimulated saliva of patients with periodontitis compared to healthy subjects. Peroxidase (p < 0.0001), catalase (p < 0.0001) and superoxide dismutase (p < 0.0001) showed lower activity in stimulated saliva of patients with periodontitis compared to healthy subjects. The peroxidase (p < 0.0029), catalase (p < 0.0001), and glutathione reductase (p = 0.0028) activity in GCF of stage III + IV were significantly higher compared to healthy controls. Superoxide dismutase (p < 0.0001) showed lower activity in GCF of patients with periodontitis. Conclusions: The demonstrated decrease in activity of all analyzed enzymatic antioxidants in non‐stimulated saliva may result from long‐lasting periodontitis and exhaustion of the safeguard mechanism against reactive oxygen species. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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