Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models.

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  • Author(s): Bosetti F;Bosetti F
  • Source:
    Journal of neurochemistry [J Neurochem] 2007 Aug; Vol. 102 (3), pp. 577-86. Date of Electronic Publication: 2007 Apr 02.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Intramural; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3042 (Print) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE
    • Publication Information:
      Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry
      Original Publication: New York : Raven Press
    • Subject Terms:
      Arachidonic Acid/*metabolism ; Brain/*metabolism ; Phospholipases A/*metabolism ; Prostaglandin-Endoperoxide Synthases/*metabolism; Animals ; Brain/physiopathology ; Brain Diseases/genetics ; Brain Diseases/metabolism ; Brain Diseases/physiopathology ; Mice ; Mice, Knockout/genetics ; Mice, Knockout/metabolism ; Models, Biological ; Prostaglandins/biosynthesis
    • Abstract:
      The arachidonic acid (AA) cascade involves the release of AA from the membrane phospholipids by a phospholipase A(2), followed by its subsequent metabolism to bioactive prostanoids by cyclooxygenases coupled with terminal synthases. Altered brain AA metabolism has been implicated in neurological, neurodegenerative, and psychiatric disorders. The development of genetically altered mice lacking specific enzymes of the AA cascade has helped to elucidate the individual roles of these enzymes in brain physiology and pathology. The roles of AA and its metabolites in brain physiology, with a particular emphasis on the phospholipase A(2)/cyclooxygenases pathway, are summarized, and the specific phenotypes of genetically altered mice relevant to brain physiology and neurotoxic models are discussed.
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      104
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    • Grant Information:
      Z01 AG000423-02 United States AG NIA NIH HHS; United States Intramural NIH HHS
    • Accession Number:
      0 (Prostaglandins)
      27YG812J1I (Arachidonic Acid)
      EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
      EC 3.1.1.32 (Phospholipases A)
    • Publication Date:
      Date Created: 20070404 Date Completed: 20071015 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC2084377
    • Accession Number:
      10.1111/j.1471-4159.2007.04558.x
    • Accession Number:
      17403135