Manual censoring of impedance tracings by the Wingate consensus reduces the number of impedance episodes, impacting on reflux categorization.

Background: The Lyon consensus classifies the evidence of gastroesophageal reflux (GERD) based on endoscopic features and results of pH/impedance monitoring (pH‐MII) including the post‐reflux swallow‐induced peristaltic wave index (PSPWI) and mean nocturnal baseline impedance (MNBI). The Wingate consensus established criteria to reduce inter‐reviewer variability when assessing reflux episodes and PSPWI by impedance. This study aims to assess the influence of the Wingate criteria on the different pH‐MII parameters obtained by automated analysis. Methods: Thirty consecutive pH‐MII off PPI were reviewed according to Wingate criteria. Number of impedance episodes and PSPWI were compared before and after censoring from automatic analysis. Reflux categorization according to Lyon consensus between censored and uncensored data was compared. Pearson correlations between impedance parameters and censored episodes were calculated. Key Results: Censoring the tracings significantly reduced the number of reflux episodes (66 [42–90.25] vs. 44.5 [21.5–61.5], p = 0.0105). Reasons for censoring were as follows: 1/ anterograde episode: 9.5 [6–13], 2/ impedance drop <50%: 1 [0–3], 3/ duration <4 s: 1 [0–2], 4/ <2 distal channels: 2.5 [1–4], and 5/ artifacts: 2 [1–5]. Censored episodes were in majority non‐acid (16.5 [13–26.5] vs. 2 [0–4], p < 0.00001). Censoring altered the categorization of impedance episodes (<40 episodes, 6 vs. 13 for resp. uncensored vs. censored tracings, 40–80 episodes: 13 vs. 13, and >80 episodes: 11 vs. 4, p = 0.0264), but not the symptom index, the symptom association probability, or the categorization according to the Lyon consensus. Nevertheless, individual tracings were affected. The percentage of censored episodes was inversely correlated with the number of acidic impedance episodes (r = −0.62, p = 0.0002). Conclusion and inferences: Manual interpretation of impedance tracings based on the Wingate consensus reduces the number of impedance episodes, impacting on reflux categorization. Acidic reflux episodes are less likely to be censored, harboring a potential at improving automatic pH‐MII analysis. [ABSTRACT FROM AUTHOR]

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