Antibacterial Lanostane Triterpenoids from the Fruiting Bodies of Ganoderma tsugae.

A phytochemical investigation on the ethanol extract from the fruiting bodies of Ganoderma tsugae resulted in the isolation of two undescribed lanostane triterpenoids, lanosta-8,24E-dien-3,7,11-trioxo-26,27-dihydroxy (1) and 22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3β-acetyloxy-15-hydroxy-20-oxo (2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The in vitro pharmacological studies revealed 2 possessed antibacterial activity against 5 anaerobic bacteria with MIC values less than 30 μg/mL. [ABSTRACT FROM AUTHOR]

Copyright of Chemistry of Natural Compounds is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)