Findings in the Area of Chronic Constriction Injury Reported from Zhejiang University (Sp1 Inhibits Pgc-1a Via Hdac2-catalyzed Histone Deacetylation In Chronic Constriction Injury-induced Neuropathic Pain).

A study conducted by researchers at Zhejiang University in China has found that the protein Sp1 plays a role in chronic constriction injury (CCI)-induced neuropathic pain. The researchers discovered that Sp1 promotes histone deacetylation in the PGC-1 alpha promoter, inhibiting the expression of PGC-1 alpha, which is associated with neuropathic pain. Silencing Sp1 in rats with CCI-induced neuropathic pain resulted in improved pain symptoms and reduced inflammation and oxidative stress. The study concludes that Sp1 exacerbates neuropathic pain through the HDAC2/PGC-1 alpha axis. [Extracted from the article]

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