Can cystatin C replace creatinine to estimate glomerular filtration rate? A literature review.

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  • Author(s): Zahran A;Zahran A; El-Husseini A; Shoker A
  • Source:
    American journal of nephrology [Am J Nephrol] 2007; Vol. 27 (2), pp. 197-205. Date of Electronic Publication: 2007 Mar 15.
  • Publication Type:
    Comparative Study; Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 8109361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9670 (Electronic) Linking ISSN: 02508095 NLM ISO Abbreviation: Am J Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel ; New York : Karger, [1981-
    • Subject Terms:
      Glomerular Filtration Rate*; Creatinine/*blood ; Cystatins/*blood ; Kidney Diseases/*blood; Biomarkers/blood ; Cystatin C ; Humans ; Kidney Transplantation ; Models, Biological
    • Abstract:
      Background: With the increasing knowledge that estimation of glomerular filtration rate (GFR) from serum creatinine (Scr) has limited value, researchers have developed new equations based on serum cystatin C (Cys C).
      Aim: To compare the performance of serum Cys C and Cys C-based GFR equations to Scr and Scr-based GFR equations.
      Methods: A Medline literature search for studies in English.
      Results: Fourteen studies in kidney transplant patients and 29 in patients with native kidney disease were identified. 70% of studies on transplants favored Cys C over Scr while 60% favored serum Cys C over Scr in patients with native kidney disease. Three studies in transplant patients and 6 in patients with native kidney disease compared the performances of Cys C- and Scr-based equations. 70% of the studies performed on transplantation favored Cys C, while 85% the studies performed in native kidney diseases showed superiority of Cys C-based equations.
      Conclusion: A large number of studies favor Cys C over Scr for the estimation of GFR. Still, many reports show no superiority of Cys C over Scr. Consistent with this, more studies are needed to study the performance of Cys C-based GFR equations.
      (Copyright 2007 S. Karger AG, Basel.)
    • Number of References:
      77
    • Accession Number:
      0 (Biomarkers)
      0 (CST3 protein, human)
      0 (Cystatin C)
      0 (Cystatins)
      AYI8EX34EU (Creatinine)
    • Publication Date:
      Date Created: 20070316 Date Completed: 20070426 Latest Revision: 20220409
    • Publication Date:
      20231215
    • Accession Number:
      10.1159/000100907
    • Accession Number:
      17361076