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Wando Mount Pleasant Library
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Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study.
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- Author(s): Ocadlikova, Darina; Lussana, Federico; Fracchiolla, Nicola; Bonifacio, Massimiliano; Santoro, Lidia; Delia, Mario; Chiaretti, Sabina; Pasciolla, Crescenza; Cignetti, Alessandro; Forghieri, Fabio; Grimaldi, Francesco; Corradi, Giulia; Zannoni, Letizia; De Propris, Stefania; Borleri, Gian Maria; Tanasi, Ilaria; Vadakekolathu, Jayakumar; Rutella, Sergio; Guarini, Anna Rita; Foà, Robin
- Source:
British Journal of Haematology; Nov2023, Vol. 203 Issue 4, p637-650, 14p- Subject Terms:
- Source:
- Additional Information
- Abstract: Summary: Blinatumomab is the first bi‐specific T‐cell engager approved for relapsed or refractory B‐cell precursor acute lymphoblastic leukaemia (B‐ALL). Despite remarkable clinical results, the effects of blinatumomab on the host immune cell repertoire are not fully elucidated. In the present study, we characterized the peripheral blood (PB) and, for the first time, the bone marrow (BM) immune cell repertoire upon blinatumomab treatment. Twenty‐nine patients with B‐ALL received blinatumomab according to clinical practice. Deep multiparametric flow cytometry was used to characterize lymphoid subsets during the first treatment cycle. Blinatumomab induced a transient redistribution of PB effector T‐cell subsets and Treg cells with a persistent increase in cytotoxic NK cells, which was associated with a transient upregulation of immune checkpoint receptors on PB CD4 and CD8 T‐cell subpopulations and of CD39 expression on suppressive Treg cells. Of note, BM immune T‐cell subsets showed a broader post‐treatment subversion, including the modulation of markers associated with a T‐cell‐exhausted phenotype. In conclusion, our study indicates that blinatumomab differentially modulates the PB and BM immune cell repertoire, which may have relevant clinical implications in the therapeutic setting. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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