Nested Case-Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts.

PANCREATIC tumors; ADENOCARCINOMA; LIFESTYLES; CONFIDENCE intervals; POLLUTANTS; LIQUID chromatography; BILE duct adenocarcinoma; PERSISTENT pollutants; CASE-control method; DIABETES; FLUOROCARBONS; DUCTAL carcinoma; GAS chromatography; SURVEYS; MASS spectrometry; MEDICAL history taking; QUESTIONNAIRES; SMOKING; NATIONAL Cancer Institute (U.S.); LOGISTIC regression analysis; ODDS ratio; DATA analysis software

The article discusses the results of a study on the effect of per- and polyfluoroalkyl substances on the incidence of pancreatic cancer. Topics mentioned include the link of prediagnostic perfluorooctanoate and levels of perfluorooctane sulfonate serum with pancreatic ductal adenocarcinoma, the characteristics of patients participated in the Alpha-Tocopherol, Beta-Carotene study and the prostate, lung, colorectal and ovarian cancer screen trial, and the use of logistic regression models.