The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction.

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  • Additional Information
    • Source:
      Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
      Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
    • Subject Terms:
      Surface Plasmon Resonance*; CD2 Antigens/*chemistry ; CD58 Antigens/*chemistry; Animals ; Antigens, CD/chemistry ; Antigens, CD/metabolism ; CD2 Antigens/metabolism ; CD48 Antigen ; CD58 Antigens/metabolism ; Humans ; Killer Cells, Natural/chemistry ; Killer Cells, Natural/metabolism ; Osmolar Concentration ; Protein Binding ; Protein Structure, Quaternary ; Rodentia ; Static Electricity ; T-Lymphocytes/chemistry ; T-Lymphocytes/metabolism
    • Abstract:
      CD2 is a T cell surface molecule that enhances T and natural killer cell function by binding its ligands CD58 (humans) and CD48 (rodents) on antigen-presenting or target cells. Here we show that the CD2/CD58 interaction is enthalpically driven and accompanied by unfavorable entropic changes. Taken together with structural studies, this indicates that binding is accompanied by energetically significant conformational adjustments. Despite having a highly charged binding interface, neither the affinity nor the rate constants of the CD2/CD58 interaction were affected by changes in ionic strength, indicating that long-range electrostatic forces make no net contribution to binding.
    • References:
      J Mol Biol. 2001 Sep 28;312(4):711-20. (PMID: 11575926)
      Biophys Chem. 1997 Feb 28;64(1-3):15-23. (PMID: 9127935)
      Chem Biol. 1996 Oct;3(10):791-801. (PMID: 8939696)
      Protein Sci. 1997 Mar;6(3):534-42. (PMID: 9070436)
      J Exp Med. 1999 Nov 15;190(10):1371-4. (PMID: 10562312)
      Proteins. 1997 Jun;28(2):153-61. (PMID: 9188733)
      Proc Natl Acad Sci U S A. 1998 May 12;95(10):5490-4. (PMID: 9576909)
      Biochemistry. 2001 Feb 13;40(6):1774-8. (PMID: 11327839)
      Immunol Rev. 1989 Oct;111:111-44. (PMID: 2576417)
      Chem Rev. 1997 Aug 5;97(5):1233-1250. (PMID: 11851449)
      Immunity. 1999 Mar;10(3):357-65. (PMID: 10204491)
      Trends Biochem Sci. 1994 Sep;19(9):354-8. (PMID: 7985226)
      Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11613-7. (PMID: 7505442)
      Anal Biochem. 1995 Jul 1;228(2):274-80. (PMID: 8572306)
      J Biol Chem. 2007 Feb 23;282(8):5589-96. (PMID: 17172599)
      Protein Sci. 1995 Dec;4(12):2559-61. (PMID: 8580846)
      Nat Struct Biol. 1996 May;3(5):427-31. (PMID: 8612072)
      J Immunol. 1994 Feb 1;152(3):1228-36. (PMID: 8301128)
      J Mol Biol. 1994 May 20;238(5):777-93. (PMID: 8182748)
      Biochemistry. 1995 Jan 17;34(2):632-8. (PMID: 7819258)
      Cell. 1999 Jun 11;97(6):791-803. (PMID: 10380930)
      Biochemistry. 2003 Apr 29;42(16):4709-16. (PMID: 12705834)
      Science. 1994 Feb 11;263(5148):777-84. (PMID: 8303294)
      J Exp Med. 1993 Aug 1;178(2):549-58. (PMID: 7688025)
      Proteins. 1994 Jan;18(1):63-7. (PMID: 8146122)
      Biochemistry. 1994 Aug 23;33(33):10149-60. (PMID: 7520278)
      J Biol Chem. 1992 Apr 25;267(12):8371-6. (PMID: 1373726)
      J Exp Med. 1999 Nov 15;190(10):1383-92. (PMID: 10562314)
      Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5597-9. (PMID: 7777555)
      Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9026-31. (PMID: 10922058)
      J Mol Biol. 1999 Feb 5;285(5):2177-98. (PMID: 9925793)
      Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2064-8. (PMID: 10688878)
      Annu Rev Immunol. 2003;21:659-84. (PMID: 12615890)
      Science. 1995 May 26;268(5214):1144-9. (PMID: 7761829)
      Nature. 1989 Jan 5;337(6202):73-5. (PMID: 2462676)
      Mol Cell. 2003 Dec;12(6):1367-78. (PMID: 14690592)
      Immunol Today. 1996 Apr;17(4):177-87. (PMID: 8871350)
      Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4289-94. (PMID: 10200255)
      Biochemistry. 2002 Jun 11;41(23):7501-7. (PMID: 12044184)
      J Immunol. 2000 Apr 1;164(7):3591-5. (PMID: 10725714)
      Science. 1995 Sep 1;269(5228):1273-8. (PMID: 7544493)
      Nat Rev Immunol. 2003 Oct;3(10):813-21. (PMID: 14523387)
      Curr Opin Struct Biol. 2002 Feb;12(1):41-7. (PMID: 11839488)
      J Mol Biol. 2005 Feb 18;346(2):533-50. (PMID: 15670602)
      Structure. 1994 Aug 15;2(8):755-66. (PMID: 7994575)
      J Biol Chem. 2006 Sep 29;281(39):29309-20. (PMID: 16803907)
      J Mol Graph. 1995 Oct;13(5):323-30, 307-8. (PMID: 8603061)
      J Exp Med. 2004 Dec 6;200(11):1455-66. (PMID: 15583017)
      Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6818-23. (PMID: 11391002)
      EMBO J. 1999 Jun 1;18(11):2941-9. (PMID: 10357807)
      J Exp Med. 1994 Nov 1;180(5):1861-71. (PMID: 7525842)
      J Mol Biol. 1971 Feb 14;55(3):379-400. (PMID: 5551392)
      Curr Opin Struct Biol. 2000 Apr;10(2):153-9. (PMID: 10753808)
      Immunol Rev. 1998 Jun;163:217-36. (PMID: 9700513)
      Immunol Rev. 1989 Oct;111:267-94. (PMID: 2483402)
    • Grant Information:
      United Kingdom WT_ Wellcome Trust; 081894 United Kingdom WT_ Wellcome Trust; G19/31 United Kingdom MRC_ Medical Research Council; G9722488 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Indexing Agency: NLM Local ID #: UKMS27967.
    • Accession Number:
      0 (Antigens, CD)
      0 (CD2 Antigens)
      0 (CD48 Antigen)
      0 (CD48 protein, human)
      0 (CD58 Antigens)
    • Publication Date:
      Date Created: 20070309 Date Completed: 20070614 Latest Revision: 20220323
    • Publication Date:
      20240829
    • Accession Number:
      PMC2771598
    • Accession Number:
      10.1074/jbc.M700829200
    • Accession Number:
      17344209