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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. - 4 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 6 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 6 p.m.
Phone: (843) 889-3300
Otranto Road Library
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Phone: (843) 572-4094
Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Phone: (843) 559-1945
Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Phone: (843) 795-6679
Main Library
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Phone: (843) 805-6930
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Phone: (843) 805-6892
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Phone: (843) 805-6909
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Conventional Tools for Predicting Satisfactory Response to Neoadjuvant Chemotherapy in HR+/HER2− Breast Cancer Patients.
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- Author(s): Oprea, Adela Luciana; Gulluoglu, Bahadir; Aytin, Yusuf Emre; Eren, Ozgur Can; Aral, Canan; Szekely, Tiberiu- Bogdan; Tastekin, Ebru; Kaya, Handan; Bademler, Süleyman; Karanlık, Hasan; Sezer, Atakan; Ugurlu, Mustafa Umit; Turdean, Sabin Gligore; Georgescu, Rares; Marginean, Claudiu
- Source:
Breast Care; 2023, Vol. 18 Issue 5, p344-353, 10p- Subject Terms:
ADJUVANT chemotherapy; STATISTICS; DOXORUBICIN; RETROSPECTIVE studies; MANN Whitney U Test; ANTINEOPLASTIC agents; TREATMENT effectiveness; COMPARATIVE studies; GENE expression; ESTROGEN receptors; HYDROCARBONS; DESCRIPTIVE statistics; CYCLOPHOSPHAMIDE; RESEARCH funding; COMBINED modality therapy; PREDICTION models; TUMOR markers; DATA analysis software; BREAST tumors; OVERALL survival; LONGITUDINAL method; PROGESTERONE receptors; FAMILY history (Medicine); EVALUATION - Source:
- Additional Information
- Subject Terms:
- Abstract: Aim: The aim of the study was to assess the role of Magee Equation 3 (MagEq3), IHC4 score, and HER2-low status in predicting "satisfactory response (SR)" to neoadjuvant chemotherapy (NAC) in HR+/HER2− breast cancer (BC) patients. Methods: In a retrospective study, female patients of any age with T
1–4 , N0–2 , M0 HR+/HER2− BC who received NAC and underwent adequate locoregional surgical treatment were included. Patients were grouped according to 2 outcomes: (a) overall response to NAC in breast and axilla by using residual cancer burden (RCB) criteria and (b) axillary downstaging after NAC by using N staging. 2 cohorts for overall response were overall SR (RCB 0–1) and no SR (RCB 2–3). On the other hand, for axillary downstaging, 2 cohorts constituted from axillary SR (ypN0 and ypN0i+ ) and no SR (ypNmic-N3 ). MagEq3 and IHC4 scores were calculated from their pathological tumor slides in each patient. HER2 status was categorized as either "no" or "low." In addition, patient age, family history, tumor histology, stage at admission, and Ki-67 status were compared between cohorts according to predefined outcomes. Results: In a total of 230 BC patients, 228 patients were included to compare according to their RCB levels. The mean age of patients with overall SR was significantly lower than those without. Patients with high Ki-67 expression, high (>30) MagEq3 score, high ICH4 quartile, and HER2-low status had significantly more overall SR. On the other hand, only patients with high Ki-67 expression had significantly more axillary SR. MagEq3 score levels, ICH4 quartiles, and HER2 status were similar between patients with axillary SR and not. Conclusion: MagEq3 and IHC4 tools seemed to be useful to predict those HR+/HER2− BC patients who are most likely to get benefit from NAC. But, only high Ki-67 expression level significantly predicted satisfactory axillary downstaging in HR+/HER2− BC patients. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Breast Care is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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