RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation.

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  • Additional Information
    • Source:
      Publisher: British Editorial Society of Bone and Joint Surgery Country of Publication: England NLM ID: 0375355 Publication Model: Print Cited Medium: Print ISSN: 0301-620X (Print) Linking ISSN: 0301620X NLM ISO Abbreviation: J Bone Joint Surg Br Subsets: MEDLINE
    • Publication Information:
      Publication: <1987>-2012: London : British Editorial Society of Bone and Joint Surgery
      Original Publication: London : Published for the British Editorial Society of Bone & Joint Surgery by Churchill Livingstone
    • Subject Terms:
      External Fixators*; Bone Morphogenetic Proteins/*therapeutic use ; Fracture Fixation/*methods ; Fracture Healing/*drug effects ; Tibial Fractures/*drug therapy ; Transforming Growth Factor beta/*therapeutic use; Adult ; Aged ; Bone Morphogenetic Protein 7 ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Fractures, Ununited/surgery ; Humans ; Male ; Middle Aged ; Radiography ; Recombinant Proteins/therapeutic use ; Reoperation ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Time Factors ; Treatment Outcome
    • Abstract:
      External fixation of distal tibial fractures is often associated with delayed union. We have investigated whether union can be enhanced by using recombinant bone morphogenetic protein-7 (rhBMP-7). Osteoinduction with rhBMP-7 and bovine collagen was used in 20 patients with distal tibial fractures which had been treated by external fixation (BMP group). Healing of the fracture was compared with that of 20 matched patients in whom treatment was similar except that rhBMP-7 was not used. Significantly more fractures had healed by 16 (p=0.039) and 20 weeks (p=0.022) in the BMP group compared with the matched group. The mean time to union (p=0.002), the duration of absence from work (p=0.018) and the time for which external fixation was required (p=0.037) were significantly shorter in the BMP group than in the matched group. Secondary intervention due to delayed healing was required in two patients in the BMP group and seven in the matched group. RhBMP-7 can enhance the union of distal tibial fractures treated by external fixation.
    • Accession Number:
      0 (BMP7 protein, human)
      0 (Bone Morphogenetic Protein 7)
      0 (Bone Morphogenetic Proteins)
      0 (Recombinant Proteins)
      0 (Transforming Growth Factor beta)
    • Publication Date:
      Date Created: 20070227 Date Completed: 20070709 Latest Revision: 20161124
    • Publication Date:
      20231215
    • Accession Number:
      10.1302/0301-620X.89B2.18230
    • Accession Number:
      17322450