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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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St. Paul's/Hollywood Library
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Bergenin Inhibits Tumor Growth and Overcomes Radioresistance by Targeting Aerobic Glycolysis.
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- Author(s): Li, Xiaoying (AUTHOR); Xie, Li (AUTHOR); Zhou, Li (AUTHOR); Gan, Yu (AUTHOR); Han, Shuangze (AUTHOR); Zhou, Yuanfeng (AUTHOR); Qing, Xiang (AUTHOR); Li, Wei (AUTHOR)
- Source:
American Journal of Chinese Medicine. 2023, Vol. 51 Issue 7, p1905-1925. 21p. - Source:
- Additional Information
- Subject Terms: IN vitro studies; BIOLOGICAL models; MOUTH tumors; IN vivo studies; ANALYSIS of variance; WESTERN immunoblotting; ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; WARBURG Effect (Oncology); T-test (Statistics); DESCRIPTIVE statistics; RESEARCH funding; PLANT extracts; CELL lines; DATA analysis software; MICE
- Abstract: Hexokinase 2 (HK2), the first glycolytic rate-limiting enzyme, is closely correlated with the occurrence and progression of tumors. Effective therapeutic agents targeting HK2 are urgently needed. Bergenin has exhibited various pharmacological activities, such as antitumor properties. However, the effects of bergenin on the abnormal glucose metabolism of cancer cells are yet unclear. In this study, HK2 was overexpressed in OSCC tissues, and the depletion of HK2 inhibited the growth of OSCC cells in vitro and in vivo. Moreover, these results showed that the natural compound, bergenin, exerted a robust antitumor effect on OSCC cells. Bergenin inhibited cancer cell proliferation, suppressed glycolysis, and induced intrinsic apoptosis in OSCC cells by downregulating HK2. Notably, bergenin restored the antitumor efficacy of irradiation in the radioresistant OSCC cells. A mechanistic study revealed that bergenin upregulated the protein level of phosphatase and the tensin homolog deleted on chromosome 10 (PTEN) by enhancing the interaction between PTEN and ubiquitin-specific protease 13 (USP13) and stabilizing PTEN; this eventually inhibited AKT phosphorylation and HK2 expression. Bergenin was identified as a novel therapeutic agent against glycolysis to inhibit OSCC and overcome radioresistance. Targeting PTEN/AKT/HK2 signaling could be a promising option for clinical OSCC treatment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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