Research Progress and New Perspectives of Anticancer Effects of Emodin.

THERAPEUTIC use of antimetabolites; MITOCHONDRIAL physiology; PROTEINS; CELL differentiation; QUINONE; ENDOPLASMIC reticulum; INFLAMMATION; CANCER chemotherapy; ANTINEOPLASTIC agents; CASCARA sagrada; NF-kappa B; APOPTOSIS; CURCUMIN; MEDICAL care; CELLULAR signal transduction; CELL motility; CELL cycle; GEMCITABINE; AFATINIB; GEFITINIB; FLUOROURACIL; GENES; PATHOLOGIC neovascularization; CISPLATIN; SORAFENIB; RADIATION-sensitizing agents; MOLECULAR structure; MITOGEN-activated protein kinases; TUMORS; TRANSCRIPTION factors; COMBINED modality therapy; MEDICAL research; CHINESE medicine; DRUG resistance in cancer cells; NANOPARTICLES; PHARMACODYNAMICS

Emodin is a natural compound found in several traditional Chinese medicines, including Rheum palmatum and Polygonum cuspidatum. Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction of apoptosis, and suppression of tumor angiogenesis and metastasis. In this review, we provide an overview of recent research progress and new perspectives on emodin's anticancer effect. We summarize the current understanding of the molecular mechanisms underlying emodin's anticancer activity, including its effects on signaling pathways such as the PI3K/Akt, MAPK, and NF- κ B pathways. We also discuss the potential of emodin as a therapeutic agent for cancer treatment, including its use in combination with conventional chemotherapeutic drugs and as a sensitizer for radiotherapy. Furthermore, we highlight recent advances in the development of emodin derivatives and their potential as novel anticancer agents. Finally, we discuss the challenges and opportunities for the translation of emodin's anticancer properties into clinical applications, including the need for further preclinical and clinical studies to evaluate its safety and efficacy. In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment. [ABSTRACT FROM AUTHOR]

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