Chinese weight-correction model for maternal serum markers in Down syndrome prenatal screening.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Wang YY;Wang YY; Zhang L; Peng ZQ; Cui QZ; Ma X
  • Source:
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2007 Apr; Vol. 97 (1), pp. 21-5. Date of Electronic Publication: 2007 Feb 07.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0020-7292 (Print) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE
    • Publication Information:
      Publication: 2017- : Malden, MA : Wiley
      Original Publication: [New York, NY] Hoeber Medical Division, Harper & Row, [c1969-
    • Subject Terms:
      Models, Statistical*; Biomarkers/*blood ; Chorionic Gonadotropin, beta Subunit, Human/*blood ; Down Syndrome/*diagnosis ; alpha-Fetoproteins/*analysis; Adult ; Asian People ; China ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second ; Prenatal Diagnosis
    • Abstract:
      Objective: To determine the best weight-correction model by means of analyzing the relationship between maternal weight and maternal serum markers when screening for Down syndrome in China.
      Methods: Serum levels of alpha-fetoprotein (AFP) and free beta-human chorionic gonadotropin (hCG) were measured in 35,917 Chinese women during the second semester of a normal singleton pregnancy and converted to multiple of median (MoM) values. Using 2 methods of statistical analysis, the all-point method and the median regression method, 4 weight-correction models were then tried, the simple linear, reciprocal, quadratic, and log-linear regression models.
      Results: The median regression method performed better than the all-point method, and the quadratic regression model showed the best fit for both AFP and hCG in the median regression method, with adjusted R(2)s of 0.987 and 0.988, respectively.
      Conclusion: The quadratic regression model was found to be the most suitable for Chinese pregnant women.
    • Accession Number:
      0 (Biomarkers)
      0 (Chorionic Gonadotropin, beta Subunit, Human)
      0 (alpha-Fetoproteins)
    • Publication Date:
      Date Created: 20070210 Date Completed: 20070529 Latest Revision: 20221207
    • Publication Date:
      20240628
    • Accession Number:
      10.1016/j.ijgo.2006.11.013
    • Accession Number:
      17289050