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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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St. Paul's/Hollywood Library
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Otranto Road Library
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Dorchester Road Library
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John L. Dart Library
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Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine.
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- Author(s): Yu, Shanhe1,2 (AUTHOR); Lin, Yingni1,2,3 (AUTHOR); Li, Yong1,2,3 (AUTHOR); Chen, Shijun1 (AUTHOR); Zhou, Lina1,2,3 (AUTHOR); Song, Hejie1,2,3 (AUTHOR); Yang, Cuiping4 (AUTHOR); Zhang, Haiqing2,3 (AUTHOR); Zhou, Jianping2,3 (AUTHOR); Sun, Shunchang5 (AUTHOR); Li, Yanan2,3 (AUTHOR); Chen, Juan1 (AUTHOR); Feng, Ruixue1 (AUTHOR); Qiao, Niu1 (AUTHOR); Xie, Yinyin1 (AUTHOR); Zhang, Ruihong1 (AUTHOR); Yin, Tong1 (AUTHOR); Chen, Saijuan1 (AUTHOR) ; Li, Qingyun1,2,3 (AUTHOR) ; Zhu, Jiang1,2 (AUTHOR)
- Source:
Cell. Oct2023, Vol. 186 Issue 21, p4615-4615. 1p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: SARS-CoV-2 primary strain-based vaccination exerts a protective effect against Omicron variants-initiated infection, symptom occurrence, and disease severity in a booster-dependent manner. Yet, the underlying mechanisms remain unclear. During the 2022 Omicron outbreak in Shanghai, we enrolled 122 infected adults and 50 uninfected controls who had been unvaccinated or vaccinated with two or three doses of COVID-19 inactive vaccines and performed integrative analysis of 41-plex CyTOF, RNA-seq, and Olink on their peripheral blood samples. The frequencies of HLA-DRhi classical monocytes, non-classical monocytes, and Th1-like Tem tended to increase, whereas the frequency of Treg was reduced by booster vaccine, and they influenced symptom occurrence in a vaccine dose-dependent manner. Intercorrelation and mechanistic analysis suggested that the booster vaccination induced monocytic training, which would prime monocytic activation and maturation rather than differentiating into myeloid-derived suppressive cells upon Omicron infections. Overall, our study provides insights into how booster vaccination elaborates protective immunity across SARS-CoV-2 variants. [Display omitted] • Vaccination histories with inactivated virus influence Omicron-triggered immunity • Innate immunity and Th1 cells are primed by three doses of inactivated virus vaccine • Innate immunity or T cell activation state associates with asymptomatic infection • Monocytic training by inactive vaccine prepares host to cope with Omicron challenge Analysis of immune responses induced by inactivated virus vaccines against SARS-CoV-2, with and without Omicron variant infection, provides insight into the relative effects of single and double boosting for the large population that received this form of COVID-19 vaccine. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Cell is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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