Monte Carlo method for bioluminescence tomography.

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  • Author(s): Kumar D;Kumar D; Cong WX; Wang G
  • Source:
    Indian journal of experimental biology [Indian J Exp Biol] 2007 Jan; Vol. 45 (1), pp. 58-63.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Science Communication and Information Resources, CSIR Country of Publication: India NLM ID: 0233411 Publication Model: Print Cited Medium: Print ISSN: 0019-5189 (Print) Linking ISSN: 00195189 NLM ISO Abbreviation: Indian J Exp Biol Subsets: MEDLINE
    • Publication Information:
      Publication: New Delhi : National Institute of Science Communication and Information Resources, CSIR
      Original Publication: New Delhi, Council of Scientific & Industrial Research.
    • Subject Terms:
      Monte Carlo Method*; Image Interpretation, Computer-Assisted/*methods ; Tomography/*methods; Animals ; Luminescence ; Mice ; Phantoms, Imaging
    • Abstract:
      Bioluminescence imaging plays an important role in the areas of cancer biology, cell biology, gene therapy, and so on. The 2D planar bioluminescent imaging has been transformed into a 3D framework by bioluminescence tomography (BLT) that enables bioluminescent source reconstruction in a mouse using a modality fusion approach. To solve this BLT problem, a geometrical model of the mouse is usually built from a CT/micro-CT/micro-MRI scan, which facilitates the assignment of optical parameters to various anatomical regions in the model. This optical model is then used to facilitate BLT. The forward model is based on Monte Carlo simulation to calculate the diffuse light flux on the surface of the mouse. The forward model data are used to define the imaging system and perform the BLT reconstruction. In this paper, we report the reconstruction of sources inside a heterogeneous highly scattering physical phantom to demonstrate the feasibility of this Monte Carlo based BLT method.
    • Grant Information:
      EB001685 United States EB NIBIB NIH HHS
    • Publication Date:
      Date Created: 20070126 Date Completed: 20070302 Latest Revision: 20071203
    • Publication Date:
      20221213
    • Accession Number:
      17249328