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Preoperative transfusion in sickle cell disease: a survey of practice in England.
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- Author(s): Buck, Jackie; Casbard, Angela; Llewelyn, Charlotte; Johnson, Tony; Davies, Sally; Williamson, Lorna
- Source:
European Journal of Haematology. Jul2005, Vol. 75 Issue 1, p14-21. 8p. - Source:
- Additional Information
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- Subject Terms:
- Abstract: Buck J, Casbard A, Llewelyn C, Johnson T, Davies S, Williamson L. Preoperative transfusion in sickle cell disease: a survey of practice in England.Eur J Haematol 2005: 75: 14–21.© Blackwell Munksgaard 2005.Objectives: To gather data on current preoperative transfusion practice and postoperative complications in sickle cell disease (SCD) as a prelude to a randomised trial.Methods: A prospective one year survey of 114 SCD patients undergoing elective surgery in 31 English hospitals was undertaken.Results: 43%, 39% and 23% of patients, respectively, received no transfusion, top-up and exchange transfusion preoperatively. Overall postoperative complication rates were 18%, 26% and 17%, with HbSC/HbSß+thalassaemia and 71% of obstetric and gynaecology patients were not transfused preoperatively, whereas 59% patients undergoing ENT procedures and 83% of hip replacements had top-up and exchange transfusions respectively. Multivariable logistic regression analysis revealed that having moderate/high risk procedures was a predictor of postoperative complications (OR 4.9 (95% Cl: 1.3 to 18),P = 0.017) while preoperative transfusion was not (OR 1.7, (95% Cl: 0.5 to 6),P = 0.41).Conclusion: The lack of clear benefit of transfusion confirms the need for a randomised controlled trial of transfusion vs. no transfusion in patients with HbSS and HbSß0thalassaemia. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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