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Transforming growth factor-beta inhibits coxsackievirus-mediated autoimmune myocarditis.
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- Author(s): Horwitz MS;Horwitz MS; Knudsen M; Ilic A; Fine C; Sarvetnick N
- Source:
Viral immunology [Viral Immunol] 2006 Winter; Vol. 19 (4), pp. 722-33.
- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 8801552 Publication Model: Print Cited Medium: Print ISSN: 0882-8245 (Print) Linking ISSN: 08828245 NLM ISO Abbreviation: Viral Immunol Subsets: MEDLINE
- Publication Information:
Original Publication: New York, NY : Mary Ann Liebert, Inc., c1987-
- Subject Terms:
- Abstract:
Clinical myocarditis is a precursor to dilated cardiomyopathy and a principal cause of heart failure. Nearly 30% of all recently diagnosed cases of myocarditis are attributable to infection with coxsackie B virus (CBV), the most frequently associated pathogen. CBV initially replicates in the pancreas and quickly spreads to the heart, inducing chronic autoimmunity. To determine whether immunosuppressive cytokines could act to limit the extent of autoimmunity to the heart, we infected transgenic mice that express immunosuppressive cytokines in the pancreas. Herein, we demonstrate that transgenic expression of transforming growth factor-beta (1) (TGF-beta) within the pancreatic beta cells prevented mice from developing autoimmune myocarditis after CBV infection. In contrast, transgenic expression of interleukin-4 did not inhibit virus-mediated heart disease. Furthermore, we show that TGF-beta expression reduced viral replication while promoting the recruitment of macrophages into the pancreas. These results illustrate the benefit of TGF-beta in controlling not only viral replication, but also CBV-mediated autoimmunity.
- Grant Information:
AI42231 United States AI NIAID NIH HHS
- Accession Number:
0 (Transforming Growth Factor beta)
- Publication Date:
Date Created: 20070105 Date Completed: 20070228 Latest Revision: 20071203
- Publication Date:
20240829
- Accession Number:
10.1089/vim.2006.19.722
- Accession Number:
17201667
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