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Folly Beach Library
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Wando Mount Pleasant Library
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Village Library
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Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.
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- Author(s): Li, Linjing (AUTHOR); Xu, Xuejie (AUTHOR); Wang, Xinxin (AUTHOR); Zhang, Shuang (AUTHOR); Yao, Wenkai (AUTHOR); Liu, Jiangqi (AUTHOR); Liu, Zhiqiang (AUTHOR); Yang, Pingchang (AUTHOR)
- Source:
Clinical & Experimental Immunology. Aug2023, Vol. 213 Issue 2, p155-163. 9p. 1 Diagram, 1 Chart, 5 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: The pathogenesis of immune tolerance disruption is not fully understood. Galectin-9 (Gal9) has immune regulatory functions. The objective of the present study is to assess the role of Gal9 in maintaining immune tolerance. Blood and intestinal biopsies were taken from patients with food allergy (FA). The status of tolerogenic dendritic cells (tDC) and type 1 regulatory T cells (Tr1 cells) in the samples was evaluated and used as representative parameters of immune tolerance. An FA mouse model was established to assess the role of Gal9 in maintaining immune tolerance. We found that peripheral CD11c+ CD5+ CD1d+ tDC frequency was significantly lower in FA patients as compared to health control (HC) subjects. There was no significant change in CD11c+ DC frequency between the FA group and the HC group. The expression of IL-10 in peripheral tDCs was lower in the FA group than that in the HC group. A positive correlation was detected between the serum levels of IL-10 and Gal9. The expression of Gal9 was observed in intestinal biopsies, which was positively correlated with the serum levels of Gal9 as well as serum IL-10 levels. Peripheral Tr1 cells had lower frequencies in the FA group than in the non-FA (Con) group. tDCs demonstrated the ability to generate Tr1 cells, which was weaker in the FA group as compared with the Con group. Exposure of FA tDCs to Gal9 in culture restored the ability to generate Tr1 cells. In summary, the lower frequency of tDC and Tr1 cell of FA patients was associated with the levels of Gal9. The presence of Gal9 restored the capacity of tDC to generate Tr1 cells. Fewer peripheral tolerogenic DCs in patients with food allergy. The abundance of tolerogenic DCs is associated with epithelial cell-derived galectin-9. Peripheral type 1 regulatory T cells are associated with serum galectin-9 and the frequency of tolerogenic DCs. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical & Experimental Immunology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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