Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini.

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  • Author(s): Keiser J;Keiser J; Shu-Hua X; Chollet J; Tanner M; Utzinger J
  • Source:
    Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2007 Mar; Vol. 51 (3), pp. 1096-8. Date of Electronic Publication: 2006 Dec 28.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, American Society for Microbiology
    • Subject Terms:
      Anthelmintics/*therapeutic use ; Clonorchiasis/*drug therapy ; Fasciola hepatica/*drug effects ; Fascioliasis/*drug therapy ; Opisthorchis/*drug effects ; Phenylenediamines/*therapeutic use ; Schistosoma mansoni/*drug effects ; Schistosomiasis mansoni/*drug therapy ; Schistosomiasis mansoni/*parasitology; Animals ; Clonorchiasis/parasitology ; Clonorchis sinensis/drug effects ; Cricetinae ; Fascioliasis/parasitology ; Female ; Male ; Mesocricetus ; Mice ; Opisthorchis/parasitology ; Rats ; Rats, Wistar
    • Abstract:
      We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
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    • Accession Number:
      0 (Anthelmintics)
      0 (Phenylenediamines)
      115103-15-6 (tribendimidine)
    • Publication Date:
      Date Created: 20061230 Date Completed: 20070514 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC1803157
    • Accession Number:
      10.1128/AAC.01366-06
    • Accession Number:
      17194822