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Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Jin, Hao-Ran; Wang, Jin; Wang, Zi-Jing; Xi, Ming-Jia; Xia, Bi-Han; Deng, Kai; Yang, Jin-Lin
- Source:
Journal of Hematology & Oncology; 9/12/2023, Vol. 16 Issue 1, p1-33, 33p- Subject Terms:
- Source:
- Additional Information
- Abstract: Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic reprogramming, which further affects tumor functional phenotypes and immune responses. Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid metabolic reprogramming in cancer, (2) summarize the lipid metabolic landscapes within stromal cells and immune cells in the tumor microenvironment, and clarify their roles in tumor progression, and (3) summarize potential therapeutic targets for lipid metabolism, and highlight the potential for combining such approaches with other anti-tumor therapies to provide new therapeutic opportunities for cancer patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Hematology & Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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