Effect of exercise, training, circadian rhythm, age, and sex on insulin-like growth factor-1 in the horse.

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  • Additional Information
    • Source:
      Publisher: American Society of Animal Science Country of Publication: United States NLM ID: 8003002 Publication Model: Print Cited Medium: Internet ISSN: 1525-3163 (Electronic) Linking ISSN: 00218812 NLM ISO Abbreviation: J Anim Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Champaign, IL : American Society of Animal Science
    • Subject Terms:
      Sex Characteristics*; Aging/*physiology ; Circadian Rhythm/*physiology ; Horses/*physiology ; Insulin-Like Growth Factor I/*metabolism ; Physical Conditioning, Animal/*physiology; Animals ; Body Weight ; Female ; Heart Rate ; Male ; Time Factors
    • Abstract:
      Insulin-like growth factor-1 could be a useful marker in the horse for diagnostic, selection, or forensic purposes, provided its physiological regulation is well understood. The objective of this study was to investigate factors, such as acute exercise, fitness training, time of day, sex, and age, that may influence serum IGF-1 in normal, healthy horses. Throughout a 9-wk training program, 6 geldings maintained a mean (+/- SEM) IGF-1 concentration of 302 +/- 29 ng/mL. Moderate or high intensity exercise had no effect on IGF-1 concentrations, when pre- and postexercise values were compared. Over a 24-h period, there was some variation in IGF-1 concentrations but no clear diurnal rhythm. Concentrations of IGF-1 were measured in a large population of thoroughbred horses (1,880) on 3 continents. The population deviated slightly from a normal distribution (P < 0.001) because of large IGF-1 concentrations in 10 horses. The global mean IGF-1 concentration was 310 +/- 2.2 ng/mL, with a greater mean value (P < 0.001) in gonad-intact males (336 +/- 5.6 ng/mL) than in females (303 +/- 3.2 ng/mL) or geldings (302 +/- 3.2 ng/mL). However, the greatest IGF-1 concentrations observed for all stallions, mares, and geldings were 627, 676, and 709 ng/mL, respectively. In mares and geldings, IGF-1 concentrations showed a gradual decrease with advancing age (P < 0.001), but the effect was much less marked in stallions. This study confirms that IGF-1 concentrations are stable, compared with GH concentrations, in the horse and that a meaningful measure of IGF-1 status can be obtained from a daily serum sample.
    • Accession Number:
      67763-96-6 (Insulin-Like Growth Factor I)
    • Publication Date:
      Date Created: 20061221 Date Completed: 20070125 Latest Revision: 20061220
    • Publication Date:
      20221213
    • Accession Number:
      10.2527/jas.2006-210
    • Accession Number:
      17179552