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[Screening and identification of stimulant and psychedelic drugs as acetyl-derivatives by GC-MS].
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- Author(s): Szkutová M;Szkutová M; Balíková M
- Source:
Soudni lekarstvi [Soud Lek] 2006 Oct; Vol. 51 (4), pp. 55-66.
- Publication Type:
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
- Language:
Czech
- Additional Information
- Transliterated Title:
Záchyt a identifikace budivých a psychedelických bází ve forme acetylderivátů pomocí GC-MS.
- Source:
Publisher: Státní zdravotnické nakladatelstvi Country of Publication: Czech Republic NLM ID: 9601665 Publication Model: Print Cited Medium: Print ISSN: 0371-1854 (Print) Linking ISSN: 03711854 NLM ISO Abbreviation: Soud Lek Subsets: MEDLINE
- Publication Information:
Original Publication: Praha : Státní zdravotnické nakladatelství,
- Subject Terms:
- Abstract:
With the increasing number of abused stimulant and psychedelic drugs, along with so called "dance drugs" and "new synthetic drugs" available on the Czech illegal market, there is a need to update methods in toxicological laboratories and therefore it is necessary to develop and optimalize screening and identification procedures for new toxic substances appearing in the laboratory practice. It is well known that relatively popular commercial screening immunoassays have some limits: for instance restricted amount of detectable substances, specificity and sensitivity of detection. Therefore, it is mandatory to combine or complete them with more specific methods based on a different principle. In this paper we have focused on collecting useful analytical data to introduce or complete the system of detection and identification of unknown drugs and their metabolites which can appear in biological samples by using gas chromatography-mass spectrometry (GC-MS) after preparation of relevant acetylated derivatives. The collection of experimental data involves retention indexes and mass spectra of acetylated phenylalkylamines, tryptamines and piperazines and some of their metabolites. These data are fundamental for laboratory diagnostics of drugs of abuse or intoxication and they can be useful for practical application in a number of toxicological laboratories. The mean limit of detection 0.1 ng analyte injected to GC-MS is low enough to allow the method to be successfully applied to real toxicological samples.
- Accession Number:
0 (Central Nervous System Stimulants)
0 (Hallucinogens)
- Publication Date:
Date Created: 20061219 Date Completed: 20070207 Latest Revision: 20161021
- Publication Date:
20231215
- Accession Number:
17172164
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