The Caprini Risk Score for Early Prediction of Mortality in Patients With Acute Coronary Syndrome.

Background: The Caprini Risk Score (CRS) is a validated predictive instrument for venous thrombosis. Previous investigators have shown that a high CRS is associated with a higher risk of mortality from thrombotic diseases. Objective: The aim of this study was to assess the association between the CRS and prognosis of patients with acute coronary syndrome (ACS). Methods: Secondary analysis of data from a retrospective cohort study was conducted. Patients were classified into 3 CRS-based categories (CRS ≤ 2, CRS = 3--4, and CRS ≥ 5, indicating low, medium, and high, respectively). Kaplan-Meier curves and Cox regression models were used to assess the prognosis of patients with ACS. All-cause mortality and cardiac mortality were the end points. Results: Two hundred fifty-four patients (12.8%) died during follow-up. Multivariate Cox regression models identified CRS as an independent risk factor for all-cause mortality among patients with ACS (CRS = 3--4vsCRS ≤ 2, hazard ratio: 3.268, 95%confidence interval: 1.396--7.647, P = .006; CRS ≥ 5vsCRS ≤ 2, hazard ratio: 4.099, 95% confidence interval: 1.708--9.841, P = .002). Pearson correlation analysis showed a positive correlation between CRS and fibrinogen level (r = 0.486, R² =0.765, P < .001) as well as D-dimer level (r =0.480, R² =0.465, P < .001). Conclusion: The CRS is a useful prognostic assessment instrument for patients with ACS, and the risk stratification of patients with ACS can be achieved based on their CRS at admission. [ABSTRACT FROM AUTHOR]

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