First use of ibrutinib for the treatment of post‐transplant central nervous system graft‐versus‐host disease.

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    • Abstract:
      Chronic graft-versus-host disease (cGVHD) represents a serious complication of allogeneic haematopoietic stem cell transplant that occurs in 20%-80% of patients. A leading hypothesis posits that chronic CNS-GHVD onset stems from sequential CNS infiltration of donor CD8 SP + sp T cells, donor CD4 SP + sp T cells and donor bone marrow-derived macrophages (BMDMs). 4 Polchlopek Blasiak K, Simonetta F, Vargas MI, Chalandon Y. Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation. [Extracted from the article]
    • Abstract:
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