Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy.

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  • Author(s): Sutinen J;Sutinen J; Yki-Järvinen H
  • Source:
    American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2007 Mar; Vol. 292 (3), pp. E687-92. Date of Electronic Publication: 2006 Oct 24.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0193-1849 (Print) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bethesda, MD. : American Physiological Society
    • Subject Terms:
      Antiretroviral Therapy, Highly Active/*adverse effects ; Basal Metabolism/*drug effects ; Eating/*drug effects ; Energy Metabolism/*drug effects ; HIV-Associated Lipodystrophy Syndrome/*metabolism ; Lipid Metabolism/*drug effects; Adult ; Body Composition ; Cross-Sectional Studies ; Female ; HIV-Associated Lipodystrophy Syndrome/chemically induced ; Humans ; Male ; Middle Aged ; Motor Activity
    • Abstract:
      Highly active antiretroviral therapy (HAART) is associated with metabolic adverse events such as lipodystrophy in human immunodeficiency virus (HIV)-infected patients. The objective of the present study was to evaluate the effects of HAART-associated lipodystrophy on resting energy expenditure and caloric intake. In this cross-sectional study we compared resting energy expenditure (REE) and energy intake in 30 HAART-treated patients with lipodystrophy (HAART+LD+) with 13 HAART-treated patients without lipodystrophy (HAART+LD-). REE was measured using indirect calorimetry, and energy intake was recorded as a 3-day diary of food intake. REE (5,180+/-160 vs. 4,260+/-150 J/min, P<0.01) and also REE expressed per fat-free mass (86+/-1 vs. 78+/-2 J.kg fat-free mass-1.min-1, P<0.01) were significantly higher in the HAART+LD+ than the HAART+LD- group. Rate of lipid oxidation was significantly higher in the HAART+LD+ than the HAART+LD- group. Total energy and fat intakes were significantly increased in the HAART+LD+ compared with the HAART+LD- group. These results imply that HAART-associated lipodystrophy is associated with increased REE and lipid oxidation and with increased caloric and fat intake.
    • Publication Date:
      Date Created: 20061026 Date Completed: 20070413 Latest Revision: 20070306
    • Publication Date:
      20221213
    • Accession Number:
      10.1152/ajpendo.00219.2006
    • Accession Number:
      17062843