Menu
×
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Clinical, Radiological, and Biomarkers in Prognostication of Patients Suffering from Severe Traumatic Brain Injury.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Gupta, Uday; Gupta, Pradeep Bharti; Gupta, Sona Kaushal
- Source:
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 6, p1950-1958, 9p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Background: This study aimed to investigate the prognostication of patients suffering from severe traumatic brain injury (TBI) through the assessment of clinical parameters, radiological findings, and biomarkers in a tertiary care hospital in Uttar Pradesh. Material & methods: A total of 200 patients with severe TBI were included in the study. Clinical parameters, including age, gender, mechanism of injury, associated injuries, and Glasgow Coma Scale (GCS) scores, were recorded. Radiological findings were obtained from computed tomography (CT) scans, and biomarker levels (S100B, neuron-specific enolase [NSE], and glial fibrillary acidic protein [GFAP]) were measured in blood samples collected within 24 hours of injury. The Glasgow Outcome Scale (GOS) was used to assess long-term prognosis. Multivariate analysis was conducted, and a prognostic model was developed. Results: The mean age of the patients was 45 years, with males representing 70% of the study population. Motor vehicle accidents were the most common mechanism of injury (45%), and associated injuries were observed in 60% of the patients. The distribution of initial GCS scores was as follows: GCS 3-5 (40%), GCS 6-8 (30%), and GCS 9-12 (30%). Radiological findings revealed subdural hematomas (35%), diffuse axonal injury (25%), and epidural hematomas (20%) as the most frequent patterns of brain injury. The frontal lobe (40%) was the most commonly affected brain region. Elevated levels of S100B (70%), NSE (55%), and GFAP (45%) were observed in the biomarker analysis. Higher GCS scores (9-12) were associated with a better prognosis, while elevated S100B levels were indicative of a poorer prognosis. CT scan findings, such as the presence of subdural hematomas and diffuse axonal injury, were associated with worse outcomes. The developed prognostic model demonstrated good discriminative ability, with an area under the ROC curve of 0.85. Conclusion: The study highlights the importance of clinical, radiological, and biomarker parameters in prognosticating patients with severe TBI. The integrated approach improves the accuracy of prognosis prediction, and the developed prognostic model shows potential for clinical implementation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research) is the property of Journal of Cardiovascular Disease Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.