Association of ambient PM10 and PM2.5 with coronary stenosis measured using selective coronary angiography.

Fujian Sheng (China); China

Long-term ambient particulate matter (PM) exposure exerts detrimental effects on cardiovascular health. Evidence on the relation of chronically exposed ambient PM 10 and PM 2.5 with coronary stenosis remains lacking. Our aim was to investigate the association of PM 10 and PM 2.5 with coronary stenosis in patients undergoing coronary angiography. We performed a retrospective cohort study consisting of 7513 individuals who underwent coronary angiography in Fujian Province, China, from January 2019 to December 2021. We calculated a modified Gensini score (GS) to represent the degree of stenosis in coronary arteries by selective coronary angiography. We fitted linear regressions and logistic models to assess the association of PM 10 and PM 2.5 with coronary stenosis. We employed restricted cubic splines to describe the exposure-response curves. We performed mediation analyses to assess the potential mediators. Long-term ambient PM 10 and PM 2.5 (prior three years average) exposure was significantly associated with the GS, with a breakpoint concentration of 47.5 μg/m3 and 25.8 μg/m3 for PM 10 and PM 2.5 , respectively, above which we found a linear positive exposure-response relationship of ambient PM with GS. Each 10 µg /m3 increase in PM 10 exposure (β: 4.81, 95 % CI: 0.44–9.19) and PM 2.5 exposure [β: 10.50, 95 % CI: 3.14–17.86] were positively related to the GS. The adjusted odds ratio (OR) for each 10 µg/m3 increment in PM 10 exposure on severe coronary stenosis was 1.33 (95 % CI: 1.04–1.76). Correspondingly, the adjusted OR for PM 2.5 was 1.87 (95 % CI: 1.24–2.99). The mediation analysis indicated that the effect of PM 10 on coronary stenosis may be partially mediated through total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, serum creatinine and blood urea nitrogen, and the effect of PM 2.5 may be mediated in part by hemoglobin A1c. Our study provides the first evidence that chronic ambient PM 10 and PM 2.5 exposure was associated with coronary stenosis assessed by GS in patients with suspected coronary artery disease and reveals its potential mediators. [Display omitted] ● The first study to reveal the association between particulate matter and Gensini score. ● Long term PM 10 and PM 2.5 exposure was associated with coronary stenosis. ● The effects might be mediated partially through TC, LDL-C, apo-B, SCr, BUN, and HbA1c. [ABSTRACT FROM AUTHOR]

Copyright of Ecotoxicology & Environmental Safety is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)