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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Phone: (843) 559-1945
Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Phone: (843) 805-6930
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Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort.
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- Author(s): Orso, Beatrice (AUTHOR); Mattioli, Pietro (AUTHOR); Yoon, Eun-Jin (AUTHOR); Kim, Yu Kyeong (AUTHOR); Kim, Heejung (AUTHOR); Shin, Jung Hwan (AUTHOR); Kim, Ryul (AUTHOR); Liguori, Claudio (AUTHOR); Famà, Francesco (AUTHOR); Donniaquio, Andrea (AUTHOR); Massa, Federico (AUTHOR); García, David Vállez (AUTHOR); Meles, Sanne K. (AUTHOR); Leenders, Klaus L. (AUTHOR); Chiaravalloti, Agostino (AUTHOR); Pardini, Matteo (AUTHOR); Bauckneht, Matteo (AUTHOR); Morbelli, Silvia (AUTHOR); Nobili, Flavio (AUTHOR); Lee, Jee-Young (AUTHOR)
- Source:
Neurological Sciences. Sep2023, Vol. 44 Issue 9, p3161-3168. 8p. 1 Chart, 3 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: A brain glucose metabolism pattern related to phenoconversion in patients with idiopathic/isolated REM sleep behaviour disorder (iRBDconvRP) was recently identified. However, the validation of the iRBDconvRP in an external, independent group of iRBD patients is needed to verify the reproducibility of such pattern, so to increase its importance in clinical and research settings. The aim of this work was to validate the iRBDconvRP in an independent group of iRBD patients. Methods: Forty iRBD patients (70 ± 5.59 years, 19 females) underwent brain [18F]FDG-PET in Seoul National University. Thirteen patients phenoconverted at follow-up (7 Parkinson disease, 5 Dementia with Lewy bodies, 1 Multiple system atrophy; follow-up time 35 ± 20.56 months) and 27 patients were still free from parkinsonism/dementia after 62 ± 29.49 months from baseline. We applied the previously identified iRBDconvRP to validate its phenoconversion prediction power. Results: The iRBDconvRP significantly discriminated converters from non-converters iRBD patients (p = 0.016; Area under the Curve 0.74, Sensitivity 0.69, Specificity 0.78), and it significantly predicted phenoconversion (Hazard ratio 4.26, C.I.95%: 1.18–15.39). Conclusions: The iRBDconvRP confirmed its robustness in predicting phenoconversion in an independent group of iRBD patients, suggesting its potential role as a stratification biomarker for disease-modifying trials. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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